DNA-capped nanoparticles designed for doxorubicin drug delivery

Colleen M. Alexander; Mathew M. Maye; James C. Dabrowiak

doi:10.1039/c0cc04916f

DNA-capped nanoparticles designed for doxorubicin drug delivery

Colleen M. Alexander, Mathew M. Maye, James C. Dabrowiak

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

Original language	English (US)
Pages (from-to)	3418-3420
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	12
DOIs	https://doi.org/10.1039/c0cc04916f
State	Published - Mar 8 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c0cc04916f

Cite this

@article{b578a2116ccf4073972c06ef8ca95382,

title = "DNA-capped nanoparticles designed for doxorubicin drug delivery",

abstract = "The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.",

author = "Alexander, {Colleen M.} and Maye, {Mathew M.} and Dabrowiak, {James C.}",

year = "2011",

month = mar,

day = "8",

doi = "10.1039/c0cc04916f",

language = "English (US)",

volume = "47",

pages = "3418--3420",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "12",

}

TY - JOUR

T1 - DNA-capped nanoparticles designed for doxorubicin drug delivery

AU - Alexander, Colleen M.

AU - Maye, Mathew M.

AU - Dabrowiak, James C.

PY - 2011/3/8

Y1 - 2011/3/8

N2 - The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

AB - The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

UR - http://www.scopus.com/inward/record.url?scp=79952408578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952408578&partnerID=8YFLogxK

U2 - 10.1039/c0cc04916f

DO - 10.1039/c0cc04916f

M3 - Article

C2 - 21286626

AN - SCOPUS:79952408578

SN - 1359-7345

VL - 47

SP - 3418

EP - 3420

JO - Chemical Communications

JF - Chemical Communications

IS - 12

ER -

DNA-capped nanoparticles designed for doxorubicin drug delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this