DNA-capped nanoparticles designed for doxorubicin drug delivery

Colleen M. Alexander, Mathew M Maye, James C. Dabrowiak

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

Original languageEnglish (US)
Pages (from-to)3418-3420
Number of pages3
JournalChemical Communications
Volume47
Issue number12
DOIs
StatePublished - Mar 28 2011

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Drug delivery
Doxorubicin
DNA
Nanoparticles
Pharmaceutical Preparations
Intercalation
Gold
Melting point
Hydrodynamics
Monitoring

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

DNA-capped nanoparticles designed for doxorubicin drug delivery. / Alexander, Colleen M.; Maye, Mathew M; Dabrowiak, James C.

In: Chemical Communications, Vol. 47, No. 12, 28.03.2011, p. 3418-3420.

Research output: Contribution to journalArticle

Alexander, Colleen M. ; Maye, Mathew M ; Dabrowiak, James C. / DNA-capped nanoparticles designed for doxorubicin drug delivery. In: Chemical Communications. 2011 ; Vol. 47, No. 12. pp. 3418-3420.
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