DNA-capped nanoparticles designed for doxorubicin drug delivery

Colleen M. Alexander, Mathew M. Maye, James C. Dabrowiak

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The anticancer drug, doxorubicin (DOX), was loaded onto DNA-capped gold nanoparticles (AuNP) designed for specific DOX intercalation. Drug binding was confirmed by monitoring DNA melting temperature, AuNP plasmon resonance maximum, and hydrodynamic radius increase, as a function of [DOX]/[DNA] ratio. The capacity for drug release to target DNA was confirmed.

Original languageEnglish (US)
Pages (from-to)3418-3420
Number of pages3
JournalChemical Communications
Volume47
Issue number12
DOIs
StatePublished - Mar 28 2011

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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