@article{62bb3d36dd554df8b6d4b8a608255101,
title = "Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc",
abstract = "He et al. use high-speed confocal imaging to visualize the dynamic morphology of proprioceptive sensory neurons through the transparent skin of crawling Drosophila larvae. They use machine vision to create 3D models that describe how the neurons change during locomotion. They investigate the activity of the cells and the role of Tmc channels.",
keywords = "Drosophila melanogaster, Tmc, behavior, mechanotransduction, microscopy, proprioception, sensory",
author = "Liping He and Sarun Gulyanon and {Mihovilovic Skanata}, Mirna and Doycho Karagyozov and Heckscher, {Ellie S.} and Michael Krieg and Gavriil Tsechpenakis and Marc Gershow and Tracey, {W. Daniel}",
note = "Funding Information: We thank Katherine Fisher and Melanie Chin of the Tracey laboratory for assistance with data analysis. Sangkyu Jung developed MATLAB code for tracking of neuronal soma. We thank members of the Tracey laboratory for helpful comments and discussions. We thank the Bloomington Drosophila stock center (NIH P400D018537), the Montell laboratory, and Cynthia Hughes for providing strains that were used in the study. We thank FlyBase for its essential database (NIH U41HG000739). M.K. acknowledges the Spanish Ministry of Economy and Competitiveness Severo Ochoa program (SEV-2015-0522), the Generalitat de Catalunya (Cerca, 2017 SGR 1012), and ERC starting grant MechanoSystems (no. 71524). Additional funding for this study was through grants to E.S.H. (NIH R01NS105748MG), M.G. (NSF 1455015 and NIH 1DP2EB022359) and W.D.T. (Gill Center Research Stipend and NIH R01GM086458). Funding Information: We thank Katherine Fisher and Melanie Chin of the Tracey laboratory for assistance with data analysis. Sangkyu Jung developed MATLAB code for tracking of neuronal soma. We thank members of the Tracey laboratory for helpful comments and discussions. We thank the Bloomington Drosophila stock center ( NIH P400D018537 ), the Montell laboratory, and Cynthia Hughes for providing strains that were used in the study. We thank FlyBase for its essential database ( NIH U41HG000739 ). M.K. acknowledges the Spanish Ministry of Economy and Competitiveness Severo Ochoa program ( SEV-2015-0522 ), the Generalitat de Catalunya (Cerca, 2017 SGR 1012 ), and ERC starting grant MechanoSystems (no. 71524 ). Additional funding for this study was through grants to E.S.H. ( NIH R01NS105748MG ), M.G. ( NSF 1455015 and NIH 1DP2EB022359 ) and W.D.T. ( Gill Center Research Stipend and NIH R01GM086458 ). Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = mar,
day = "18",
doi = "10.1016/j.cub.2019.02.025",
language = "English (US)",
volume = "29",
pages = "945--956.e3",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "6",
}