TY - JOUR
T1 - Direct reductive alkylation of amino acids
T2 - Synthesis of bifunctional chelates for nuclear imaging
AU - Levadala, Murali K.
AU - Banerjee, Sangeeta Ray
AU - Maresca, Kevin P.
AU - Babich, John W.
AU - Zubieta, Jon
PY - 2004/8/3
Y1 - 2004/8/3
N2 - A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)3 as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.
AB - A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)3 as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.
KW - Amino acids
KW - Bifunctional chelators
KW - Radiopharmaceuticals
KW - Reductive alkylation
KW - Sodium triacetoxyborohydride
UR - http://www.scopus.com/inward/record.url?scp=4043130469&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4043130469&partnerID=8YFLogxK
U2 - 10.1055/s-2004-829120
DO - 10.1055/s-2004-829120
M3 - Article
AN - SCOPUS:4043130469
SP - 1759
EP - 1766
JO - Synthesis
JF - Synthesis
SN - 0039-7881
IS - 11
ER -