Direct reductive alkylation of amino acids: Synthesis of bifunctional chelates for nuclear imaging

Murali K. Levadala, Sangeeta Ray Banerjee, Kevin P. Maresca, John W. Babich, Jon Zubieta

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)3 as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.

Original languageEnglish (US)
Pages (from-to)1759-1766
Number of pages8
JournalSynthesis
Issue number11
DOIs
StatePublished - Aug 3 2004

Keywords

  • Amino acids
  • Bifunctional chelators
  • Radiopharmaceuticals
  • Reductive alkylation
  • Sodium triacetoxyborohydride

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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