Abstract
A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)3 as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1759-1766 |
| Number of pages | 8 |
| Journal | Synthesis |
| Issue number | 11 |
| DOIs | |
| State | Published - Aug 3 2004 |
Keywords
- Amino acids
- Bifunctional chelators
- Radiopharmaceuticals
- Reductive alkylation
- Sodium triacetoxyborohydride
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry
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Levadala, M. K., Banerjee, S. R., Maresca, K. P., Babich, J. W., & Zubieta, J. (2004). Direct reductive alkylation of amino acids: Synthesis of bifunctional chelates for nuclear imaging. Synthesis, (11), 1759-1766. https://doi.org/10.1055/s-2004-829120