Abstract
A family of effective bifunctional chelators for technetium- and rhenium-based radiopharmaceuticals was conveniently synthesized in high yields through direct reductive N-alkylations of amino acids and their analogues with aldehydes, using NaBH(OAc)3 as an efficient reagent. The mono-, di-, tetra- and even mixed alkylated amino acid derivatives were all prepared in one-pot synthesis.
Original language | English (US) |
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Pages (from-to) | 1759-1766 |
Number of pages | 8 |
Journal | Synthesis |
Issue number | 11 |
DOIs | |
State | Published - Aug 3 2004 |
Keywords
- Amino acids
- Bifunctional chelators
- Radiopharmaceuticals
- Reductive alkylation
- Sodium triacetoxyborohydride
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry