Direct noninvasive real-time observation of thermoregulation physiology

Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation

Seth Fillioe, Paul Dent, Bin Deng, Sri Narsipur, Charles M. Peterson, Jerry Goodisman, Richard Steinmann, James Mostrom, Joseph Chaiken

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Thermoregulation is a mammalian physiological function fulfilled in large part by autonomic control of blood flow. We demonstrate the variation in hematocrit (Hct) and intravascular volume (VV) in the peripheral circulation when the external means of maintaining the initial thermal disequilibrium is removed using a PV[O]H device capable of noninvasively measuring both Hct and VV with unprecedented sensitivity, accuracy and precision on a 3 second timescale. Calibrated using an FDA approved device now in standard use for monitoring Hct during dialysis, the PV[O]H detection limit for measuring Hct variation is ±0.03 where 45% is normal. Observing the return to thermal equilibrium at 2 separate anatomic locations, we observe the return to normal homeostasis in a matter of a few minutes. Heat induced vasodilation results in an antecedent increase in plasma volume in greater proportion than for red blood cells into the dilated capillaries. At equilibrium homeostasis i.e. when there is no externally maintained thermal gradient we observe periodic fluctuations in the peripheral Hct and VV on a roughly 15 second to 1.5 minute timescale.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
EditorsAnita Mahadevan-Jansen, Warren S. Grundfest
PublisherSPIE
ISBN (Electronic)9781510623781
DOIs
StatePublished - Jan 1 2019
EventAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII 2019 - San Francisco, United States
Duration: Feb 3 2019Feb 5 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10868
ISSN (Print)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII 2019
CountryUnited States
CitySan Francisco
Period2/3/192/5/19

Fingerprint

peripheral circulation
thermoregulation
hematocrit
physiology
Body Temperature Regulation
Physiology
Hematocrit
Blood Vessels
Observation
Hot Temperature
Blood
homeostasis
Dialysis
vasodilation
Homeostasis
Thermal gradients
Equipment and Supplies
dialysis
Cells
Plasma Volume

Keywords

  • Blood
  • Hematocrit
  • Hemorrhage
  • In vivo
  • Noninvasive
  • Physiology
  • PV[O]H
  • Thermoregulation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Fillioe, S., Dent, P., Deng, B., Narsipur, S., Peterson, C. M., Goodisman, J., ... Chaiken, J. (2019). Direct noninvasive real-time observation of thermoregulation physiology: Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation. In A. Mahadevan-Jansen, & W. S. Grundfest (Eds.), Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII [1086803] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10868). SPIE. https://doi.org/10.1117/12.2509125

Direct noninvasive real-time observation of thermoregulation physiology : Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation. / Fillioe, Seth; Dent, Paul; Deng, Bin; Narsipur, Sri; Peterson, Charles M.; Goodisman, Jerry; Steinmann, Richard; Mostrom, James; Chaiken, Joseph.

Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII. ed. / Anita Mahadevan-Jansen; Warren S. Grundfest. SPIE, 2019. 1086803 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10868).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fillioe, S, Dent, P, Deng, B, Narsipur, S, Peterson, CM, Goodisman, J, Steinmann, R, Mostrom, J & Chaiken, J 2019, Direct noninvasive real-time observation of thermoregulation physiology: Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation. in A Mahadevan-Jansen & WS Grundfest (eds), Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII., 1086803, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10868, SPIE, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII 2019, San Francisco, United States, 2/3/19. https://doi.org/10.1117/12.2509125
Fillioe S, Dent P, Deng B, Narsipur S, Peterson CM, Goodisman J et al. Direct noninvasive real-time observation of thermoregulation physiology: Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation. In Mahadevan-Jansen A, Grundfest WS, editors, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII. SPIE. 2019. 1086803. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2509125
Fillioe, Seth ; Dent, Paul ; Deng, Bin ; Narsipur, Sri ; Peterson, Charles M. ; Goodisman, Jerry ; Steinmann, Richard ; Mostrom, James ; Chaiken, Joseph. / Direct noninvasive real-time observation of thermoregulation physiology : Periodic fluctuations in hematocrit and vascular volume in the peripheral circulation. Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII. editor / Anita Mahadevan-Jansen ; Warren S. Grundfest. SPIE, 2019. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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