TY - JOUR
T1 - Direct cortical stimulation
T2 - a further study of treatment intensity effects on retrograde amnesia gradients
AU - Gold, Paul E.
AU - Mcdonald, Robert
AU - Mcgaugh, James L.
N1 - Funding Information:
One difficulty with the interpretation is the widely discrepant time course for memory disruption obtained in different studies. Recent evidence 1Supported by Research Grant MH 12526 and Postdoctoral Fellowship No. 1 F02 MH 51262-01 PS from the National Institutes of Mental Health, United States Public Health Service and Undergraduate Research Participation Program Fellowship GY-10031 from the National Science Foundation.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1974/4
Y1 - 1974/4
N2 - Rats were trained on a one-trial inhibitory avoidance task; at one of several intervals (0.1 sec-15 min) after training, they received electrical stimulation of either frontal or posterior cortex. The length of the RA gradient as measured on a 24-hr retention test varied with treatment intensity, particularly for frontal cortex stimulation. These results, together with previous findings, suggest that the minimal stimulation intensity necessary to produce RA increases with time after training. However, there also seems to be a maximal cortical stimulation intensity beyond which further increases in intensity do not extend the length of the RA gradient. In addition, the present results indicate that behavioral variables alter the lengths of RA gradients.
AB - Rats were trained on a one-trial inhibitory avoidance task; at one of several intervals (0.1 sec-15 min) after training, they received electrical stimulation of either frontal or posterior cortex. The length of the RA gradient as measured on a 24-hr retention test varied with treatment intensity, particularly for frontal cortex stimulation. These results, together with previous findings, suggest that the minimal stimulation intensity necessary to produce RA increases with time after training. However, there also seems to be a maximal cortical stimulation intensity beyond which further increases in intensity do not extend the length of the RA gradient. In addition, the present results indicate that behavioral variables alter the lengths of RA gradients.
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U2 - 10.1016/S0091-6773(74)92077-X
DO - 10.1016/S0091-6773(74)92077-X
M3 - Article
C2 - 4857079
AN - SCOPUS:0016367405
VL - 10
SP - 485
EP - 490
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 4
ER -