Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

Lisa M. Savage, Qing Chang, Paul E. Gold

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.

Original languageEnglish (US)
Pages (from-to)242-246
Number of pages5
JournalLearning and Memory
Volume10
Issue number4
DOIs
StatePublished - Jul 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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