Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

Lisa M. Savage; Qing Chang; Paul E. Gold

doi:10.1101/lm.60003

Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

Lisa M. Savage, Qing Chang, Paul E. Gold

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.

Original language	English (US)
Pages (from-to)	242-246
Number of pages	5
Journal	Learning and Memory
Volume	10
Issue number	4
DOIs	https://doi.org/10.1101/lm.60003
State	Published - Jul 2003
Externally published	Yes

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

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abstract = "A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.",

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AB - A rodent model of diencephalic amnesia, pyrithiamine-induced thiamine deficiency (PTD), was used to investigate diencephalic-hippocampal interactions. Acetylcholine (ACh) release, a marker of memory-related activation, was measured in the hippocampus of PTD-treated and control rats prior to, during, and after spontaneous alternation test. During behavioral testing, all animals displayed increases in ACh release. However, both the percent increase of ACh release during spontaneous alternation testing and the alternation scores were higher in control rats relative to PTD-treated rats. Thus, when rats are tested on a task with demands dependent on the hippocampus, it appears that the hippocampus is not fully activated after diencephalic damage.

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Diencephalic damage decreases hippocampal acetylcholine release during spontaneous alternation testing

Abstract

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