TY - JOUR
T1 - Development, specification, and diversity of callosal projection neurons
AU - Fame, Ryann M.
AU - MacDonald, Jessica L.
AU - Macklis, Jeffrey D.
N1 - Funding Information:
We thank L. Pasquina for superb artistic assistance. This work was partially supported by the National Institutes of Health (Grants NS41590 and NS45523), the Harvard Stem Cell Institute, the Jane and Lee Seidman Fund for CNS Research, and the Emily and Robert Pearlstein Fund for Nervous System Repair (J.D.M.), with additional infrastructure support by National Institutes of Health Grant NS49553 (J.D.M). R.M.F. was partially supported by a National Science Foundation Graduate Research Fellowship. Appendix A
PY - 2011/1
Y1 - 2011/1
N2 - Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative connectivity, and have been implicated in cognitive syndromes of high-level associative dysfunction, such as autism spectrum disorders. CPN evolved relatively recently compared to other cortical neuron populations, and have undergone disproportionately large expansion from mouse to human. While much is known about the anatomical trajectory of developing CPN axons, and progress has been made in identifying cellular and molecular controls over midline crossing, only recently have molecular-genetic controls been identified that specify CPN populations, and help define CPN subpopulations. In this review, we discuss the development, diversity and evolution of CPN.
AB - Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative connectivity, and have been implicated in cognitive syndromes of high-level associative dysfunction, such as autism spectrum disorders. CPN evolved relatively recently compared to other cortical neuron populations, and have undergone disproportionately large expansion from mouse to human. While much is known about the anatomical trajectory of developing CPN axons, and progress has been made in identifying cellular and molecular controls over midline crossing, only recently have molecular-genetic controls been identified that specify CPN populations, and help define CPN subpopulations. In this review, we discuss the development, diversity and evolution of CPN.
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U2 - 10.1016/j.tins.2010.10.002
DO - 10.1016/j.tins.2010.10.002
M3 - Review article
C2 - 21129791
AN - SCOPUS:78650745174
SN - 0166-2236
VL - 34
SP - 41
EP - 50
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 1
ER -