Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS)

Russell Kincaid, Andrzej Krol, Sylvain Fourmaux, Jean Claude Kieffer, Cristina Serbanescu, Marina Servol, Levon Vogelsang, Steve Wilkins, Andrew Stevenson, Yakov Nesterets, Edward Lipson, Hongwei Ye, Andrew Pogany

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We are developing and exploring the imaging performance of, an in vivo, in-line holography, x-ray phase-contrast, micro-CT system with an ultrafast laser-based x-ray (ULX) source. By testing and refining our system, and by performing computer simulations, we plan to improve system performance in terms of contrast resolution and multi-energy imaging to a level beyond what can be obtained using a conventional microfocal x-ray tube. Initial CT projection sets at single energy (Mo Kα and Kβ lines) were acquired in the Fresnel regime and reconstructed for phantoms and a euthanized mouse. We also performed computer simulations of phase-contrast micro-CT scans for low-contrast, soft-tissue, tumor imaging. We determined that, in order to perform a phase-contrast, complete micro-CT scan using ULX, the following conditions must be met: (i) the x-ray source needs to be stable during the scan; (ii) the laser focal spot size needs to be less than 10 μm for source-to-object distance greater than 30 cm; (iii) the laser light intensity on the target needs to be in the range of 5 × 1017 to 5 × 1019 W/cm2; (iv) the ablation protection system needs to allow uninterrupted scans; (v) the laser light focusing on the target needs to remain accurate during the entire scan; (vi) a fresh surface of the target must be exposed to consecutive laser shots during the entire scan; (vii) the effective detector element size must be less than 12 μm. Based on the results obtained in this research project, we anticipate that the new 10 Hz, 200 TW laser with 50W average power that is being commissioned at ALLS will allow us practical implementation of in vivo x-ray phase-contrast micro-CT.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume7078
DOIs
StatePublished - 2008
EventDevelopments in X-Ray Tomography VI - San Diego, CA, United States
Duration: Aug 12 2008Aug 14 2008

Other

OtherDevelopments in X-Ray Tomography VI
CountryUnited States
CitySan Diego, CA
Period8/12/088/14/08

Fingerprint

Micro-CT
Ultrafast Lasers
Ultrafast lasers
Phase Contrast
Biomedical Applications
phase contrast
Light sources
light sources
Laser
X rays
Lasers
lasers
x rays
Computerized tomography
Imaging
Imaging techniques
Target
x ray sources
Computer Simulation
Entire

Keywords

  • In vivo micro-CT
  • In-line holography
  • Tumor imaging
  • Ultrafast laser-based x-ray source
  • X-ray phase-contrast imaging

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Kincaid, R., Krol, A., Fourmaux, S., Kieffer, J. C., Serbanescu, C., Servol, M., ... Pogany, A. (2008). Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS). In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 7078). [707818] https://doi.org/10.1117/12.795542

Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS). / Kincaid, Russell; Krol, Andrzej; Fourmaux, Sylvain; Kieffer, Jean Claude; Serbanescu, Cristina; Servol, Marina; Vogelsang, Levon; Wilkins, Steve; Stevenson, Andrew; Nesterets, Yakov; Lipson, Edward; Ye, Hongwei; Pogany, Andrew.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7078 2008. 707818.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kincaid, R, Krol, A, Fourmaux, S, Kieffer, JC, Serbanescu, C, Servol, M, Vogelsang, L, Wilkins, S, Stevenson, A, Nesterets, Y, Lipson, E, Ye, H & Pogany, A 2008, Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS). in Proceedings of SPIE - The International Society for Optical Engineering. vol. 7078, 707818, Developments in X-Ray Tomography VI, San Diego, CA, United States, 8/12/08. https://doi.org/10.1117/12.795542
Kincaid R, Krol A, Fourmaux S, Kieffer JC, Serbanescu C, Servol M et al. Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS). In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7078. 2008. 707818 https://doi.org/10.1117/12.795542
Kincaid, Russell ; Krol, Andrzej ; Fourmaux, Sylvain ; Kieffer, Jean Claude ; Serbanescu, Cristina ; Servol, Marina ; Vogelsang, Levon ; Wilkins, Steve ; Stevenson, Andrew ; Nesterets, Yakov ; Lipson, Edward ; Ye, Hongwei ; Pogany, Andrew. / Development of ultrafast laser-based x-ray in-vivo phase-contrast micro-CT beamline for biomedical applications at Advanced Laser Light Source (ALLS). Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7078 2008.
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