Development of a fully 3D system model in iterative expectation- maximization reconstruction for cone-beam SPECT

Hongwei Ye, Levon Vogelsang, David H. Feiglin, Edward D. Lipson, Andrzej Krol

Research output: Chapter in Book/Entry/PoemConference contribution


In order to improve reconstructed image quality for cone-beam collimator SPECT, we have developed and implemented a fully 3D reconstruction, using an ordered subsets expectation maximization (OSEM) algorithm, along with a volumetric system model-cone-volume system model (CVSM), a modified attenuation compensation, and a 3D depth-and angle-dependent resolution and sensitivity correction. SPECT data were acquired in a 128×128 matrix, in 120 views with a single circular orbit. Two sets of numerical Défrise phantoms were used to simulate CBC SPECT scans, and low noise and scatter-free projection dataseis were obtained using the SimSET Monte Carlo package. The reconstructed images, obtained using OSEM with a line-length system model (LLSM) and a 3D Gaussian post-filter, and OSEM with FVSM and a 3D Gaussian post-filter were quantitatively studied. Overall improvement in the image quality has been observed, including better transaxial resolution, higher contrast-to-noise ratio between hot and cold disks, and better accuracy and lower bias in OSEM-CVSM, compared with OSEM-LLSM.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physics of Medical Imaging
StatePublished - 2008
EventMedical Imaging 2008 - Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 18 2008Feb 21 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2008 - Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Cone-beam collimator SPECT
  • Cone-beam fully 3D reconstruction
  • Volumetric system models

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Development of a fully 3D system model in iterative expectation- maximization reconstruction for cone-beam SPECT'. Together they form a unique fingerprint.

Cite this