Designing quantum rods for optimized energy transfer with firefly luciferase enzymes

Rabeka Alam, Danielle M. Fontaine, Bruce R. Branchini, Mathew M. Maye

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


The bioluminescence resonance energy transfer (BRET) between firefly luciferase from Photinus pyralis (Ppy) with core/shell semiconductive quantum rods (QRs) has been studied as a function of QR aspect ratio and internal microstructure. The QRs were found to be ideal energy acceptors, and Ppy-to-core distances were optimized using rod-in-rod microstructures that were achieved by the synthetic control of rod morphology, surface chemistry, and Ppy:QR loading. The BRET ratios of >44 measured are the highest efficiencies to date.

Original languageEnglish (US)
Pages (from-to)3251-3256
Number of pages6
JournalNano Letters
Issue number6
StatePublished - Jun 13 2012


  • BRET
  • biotic/abiotic
  • energy transfer
  • quantum rods

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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