Design of supramolecular amino acids to template peptide folding

Davoud Mozhdehi, Zhibin Guan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We describe in this manuscript a new design of supramolecular amino acids (SAAs) for directing peptide folding in organic environments. The incorporated supramolecular motif has a strong driving force to dimerize in a sequence- and orientation-specific manner. By introducing such SAAs into the primary sequence of peptides, the specific and directional dimerization of the supramolecular units should facilitate the folding of the peptides. Our approach may provide a general strategy to program secondary structures in organic media.

Original languageEnglish (US)
Pages (from-to)9950-9952
Number of pages3
JournalChemical Communications
Volume49
Issue number85
DOIs
StatePublished - Oct 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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