Design of Catalytic Peptides and Proteins Through Rational and Combinatorial Approaches

Yoshiaki Maeda, Olga V. Makhlynets, Hiroshi Matsui, Ivan V. Korendovych

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

This review focuses on recent progress in noncomputational methods to introduce catalytic function into proteins, peptides, and peptide assemblies. We discuss various approaches to creating catalytic activity and classification of noncomputational methods into rational and combinatorial classes. The section on rational design covers recent progress in the development of short peptides and oligomeric peptide assemblies for various natural and unnatural reactions. The section on combinatorial design describes recent advances in the discovery of catalytic peptides. We present the future prospects of these and other new approaches in a broader context, including implications for functional material design.

Original languageEnglish (US)
Pages (from-to)311-328
Number of pages18
JournalAnnual Review of Biomedical Engineering
Volume18
DOIs
StatePublished - Jul 11 2016

Keywords

  • Catalysis
  • Metalloenzymes
  • Phage display
  • Protein design
  • Supramolecular assemblies

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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