Deformable model for 3D intramodal nonrigid breast image registration with fiducial skin markers

Mehmet Z. Unlu, Andrzej Krol, Ioana L. Coman, James A. Mandel, Karl G. Baum, Wei Lee, Edward D. Lipson, David H. Feiglin

Research output: Contribution to journalConference Articlepeer-review

3 Scopus citations


We implemented a new approach to intramodal non-rigid 3D breast image registration. Our method uses fiducial skin markers (FSM) placed on the breast surface. After determining the displacements of FSM, finite element method (FEM) is used to distribute the markers' displacements linearly over the entire breast volume using the analogy between the orthogonal components of the displacement field and a steady state heat transfer (SSHT). It is valid because the displacement field in x, y and z direction and a SSHT problem can both be modeled using LaPlace's equation and the displacements are analogous to temperature differences in SSHT. It can be solved via standard heat conduction FEM software with arbitrary conductivity of surface elements significantly higher than that of volume elements. After determining the displacements of the mesh nodes over the entire breast volume, moving breast volume is registered to target breast volume using an image warping algorithm. Very good quality of the registration was obtained. Following similarity measurements were estimated: Normalized Mutual Information (NMI), Normalized Correlation Coefficient (NCC) and Sum of Absolute Valued Differences (SAVD). We also compared our method with rigid registration technique.

Original languageEnglish (US)
Article number176
Pages (from-to)1528-1534
Number of pages7
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue numberIII
StatePublished - 2005
EventMedical Imaging 2005 - Image Processing - San Diego, CA, United States
Duration: Feb 13 2005Feb 17 2005


  • Deformable breast model
  • Fiducial skin markers
  • Finite element method
  • Intramodal image registration

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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