De novo designed peptides form a highly catalytic ordered nanoarchitecture on a graphite surface

Wei Luo, Hironaga Noguchi, Chen Chen, Yoshiki Nakamura, Chishu Homma, Oleksii Zozulia, Ivan V. Korendovych, Yuhei Hayamizu

Research output: Contribution to journalArticlepeer-review

Abstract

Here we demonstrate that short peptides, de novo designed from first principles, self-assemble on the surface of graphite to produce a highly robust and catalytic nanoarchitecture, which promotes peroxidation reactions with activities that rival those of natural enzymes in both single and multi-substrate reactions. These designable peptides recapitulate the symmetry of the underlying graphite surface and act as molecular scaffolds to immobilize hemin molecules on the electrode in a hierarchical self-assembly manner. The highly ordered and uniform hybrid graphite-peptide-hemin nanoarchitecture shows the highest faradaic efficiency of any hybrid electrode reported. Given the explosive growth of the types of chemical reactions promoted by self-assembled peptide materials, this new approach to creating complex electrocatalytic assemblies will yield highly efficient and practically applicable electrocatalysts.

Original languageEnglish (US)
Pages (from-to)8326-8331
Number of pages6
JournalNanoscale
Volume14
Issue number23
DOIs
StatePublished - May 26 2022

ASJC Scopus subject areas

  • Materials Science(all)

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