Cytogenetic analysis of chromosome region 73AD of Drosophila malanogaster

J. M. Belote, F. M. Hoffmann, M. McKeown, R. L. Chorsky, B. S. Baker

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Abstract

The 73AD salivary chromosome region of Drosophila melanogaster was subjected to mutational analysis in order to (1) generate a collection of chromosome breakpoints that would allow a correlation between the genetic, cytological and molecular maps of the region and (2) define the number and gross organization of complementation groups within this interval. Eighteen complementation groups were defined and mapped to the 73AD-73B7 region, which is comprised of 17 polytene bands. These complementation groups include the previously known scarlet (st), transformer (tra) and Dominant temperature-sensitive lethal-5 (DTS-5) genes, as well as 13 new recessive lethal complementation groups and one male and female sterile locus. One of the newly identified lethal complementation groups corresponds to the molecularly identified abl locus, and another gene is defined by mutant alleles that exhibit an interaction with the abl mutants. We also recovered several mutations in the 73C1-D1·2 interval, representing two lethal complementation groups, one new visible mutant, plucked (plk), and a previously known visible, dark body (db). There is no evidence of a complex of sex determination genes in the region near tra.

Original languageEnglish (US)
Pages (from-to)783-793
Number of pages11
JournalGenetics
Volume125
Issue number4
StatePublished - Aug 10 1990

ASJC Scopus subject areas

  • Genetics

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    Belote, J. M., Hoffmann, F. M., McKeown, M., Chorsky, R. L., & Baker, B. S. (1990). Cytogenetic analysis of chromosome region 73AD of Drosophila malanogaster. Genetics, 125(4), 783-793.