Cycloheximide impairs and enhances memory depending on dose and footshock intensity

Paul E. Gold, Sean M. Wrenn

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

This experiment examined the effects on memory of interactions of cycloheximide dose and training foot shock intensity. Mice received injections of cycloheximide (120. mg/kg, s.c.) or saline 30. min prior to inhibitory avoidance training with shock intensities of 100, 150, 250 or 300 μA (1. s duration). Memory was tested 48. h later. The saline control mice showed increasing memory latencies as a function of shock intensity. The ability of cycloheximide to impair memory increased as the training shock intensity increased. In a second experiment, mice were trained with a 200 μA (1. s duration) shock and received injections of saline or cycloheximide at one of several doses (30, 60 or 120. mg/kg). Under these training conditions, cycloheximide enhanced memory in an inverted-U dose-response manner. These findings are consistent with prior findings suggesting that protein synthesis inhibitors act on memory by altering modulators of memory formation as a secondary consequence of the inhibition of protein synthesis rather than by interfering with training-initiated synthesis of proteins required for memory formation.

Original languageEnglish (US)
Pages (from-to)293-297
Number of pages5
JournalBehavioural Brain Research
Volume233
Issue number2
DOIs
StatePublished - Aug 1 2012

Keywords

  • Consolidation
  • Cycloheximide
  • Inhibitory avoidance
  • Long-term memory
  • Memory enhancement
  • Protein synthesis

ASJC Scopus subject areas

  • Behavioral Neuroscience

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