Corrosion products generated from mechanically assisted crevice corrosion of stainless steel orthopaedic implants

Robert M. Urban, Joshua J. Jacobs, Jeremy L. Gilbert, Anastasia K. Skipor, Nadim J. Hallab, Katalin Mikecz, Tibor T. Glant, J. Lawrence Marsh, Jorge O. Galante

Research output: Contribution to journalConference Articlepeer-review

3 Scopus citations


Accelerated corrosion of metallic implants in vivo can generate both soluble and insoluble products that can be detected locally and systemically. Retrieved stainless steel implants for trauma fixation or spinal instrumentation demonstrate iron and chromium-containing solid products of corrosion deposited around corroded modular junctions and as phagocytosable particles in the adjacent tissues. In some cases, the resulting adverse local tissue reaction has been associated with pain, inflammation and osteolysis, requiring removal of the implant. In vitro cell and organ culture studies confirm that corrosion products such as particles of chromium phosphate can elicit proinflammatory cytokine secretion from macrophages and promote macrophage-mediated bone resorption. Systemically, soluble corrosion products of chromium can be detected in the serum of selected patients with accelerated corrosion of chromium-containing implants. Metal-protein binding studies indicate that the high molecular weight serum proteins including immunoglobulins have the highest affinity for chromium. These findings stress the importance of the design of modular junctions to minimize corrosion of stainless steels used in orthopaedic appliances.

Original languageEnglish (US)
Pages (from-to)262-272
Number of pages11
JournalASTM Special Technical Publication
Issue number1438
StatePublished - 2002
EventStainless Steels for Medical and Surgical Applications - Pittsburgh, PA, United States
Duration: May 6 2002May 7 2002


  • Chromium
  • Corrosion
  • Crevice
  • Cytokines
  • Fretting
  • Metal ions
  • Modularity
  • Osteolysis
  • Particulate debris
  • Serum proteins
  • Stainless steel
  • Systemic dissemination

ASJC Scopus subject areas

  • General Engineering


Dive into the research topics of 'Corrosion products generated from mechanically assisted crevice corrosion of stainless steel orthopaedic implants'. Together they form a unique fingerprint.

Cite this