Copy Number Variations

Jianguo Lu, Zhanjiang John Liu

Research output: Chapter in Book/Entry/PoemChapter

Original languageEnglish (US)
Title of host publicationNext Generation Sequencing and Whole Genome Selection in Aquaculture
PublisherWiley Blackwell
Number of pages13
ISBN (Print)9780813806372
StatePublished - Dec 10 2010
Externally publishedYes


  • Array CGH, or molecular karyotyping - techniques to scan genome for gains and losses of chromosomal segments to discover CNVs
  • CNVs, and changes in genomic architecture - deletions, insertions and duplications
  • CNVs, influencing genome expression and function - CNV polymorphism influencing performance traits
  • Computational approach, for gene CNVs analysis - among species with reference genome sequences available
  • Copy number variation (CNV), segment of DNA - copy number differences, two or more genomes
  • Genomes, and highly repetitive elements - interfering with hybridization
  • Impact of CNVs on gene expression and phenotypes
  • Methods summary, detection of structural variations - in human genome
  • Multiplex Amplifiable Probe Hybridization (MAPH) - analysis of CNV in targeted genomic regions, based on known information
  • Research on CNVs, lacking - understanding impact of CNVs and its significance in aquaculture

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences

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