Copy Number Variations

Jianguo Lu, Zhanjiang John Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationNext Generation Sequencing and Whole Genome Selection in Aquaculture
PublisherWiley Blackwell
Pages21-33
Number of pages13
ISBN (Print)9780813806372
DOIs
StatePublished - Dec 10 2010
Externally publishedYes

Keywords

  • Array CGH, or molecular karyotyping - techniques to scan genome for gains and losses of chromosomal segments to discover CNVs
  • CNVs, and changes in genomic architecture - deletions, insertions and duplications
  • CNVs, influencing genome expression and function - CNV polymorphism influencing performance traits
  • Computational approach, for gene CNVs analysis - among species with reference genome sequences available
  • Copy number variation (CNV), segment of DNA - copy number differences, two or more genomes
  • Genomes, and highly repetitive elements - interfering with hybridization
  • Impact of CNVs on gene expression and phenotypes
  • Methods summary, detection of structural variations - in human genome
  • Multiplex Amplifiable Probe Hybridization (MAPH) - analysis of CNV in targeted genomic regions, based on known information
  • Research on CNVs, lacking - understanding impact of CNVs and its significance in aquaculture

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Lu, J., & Liu, Z. J. (2010). Copy Number Variations. In Next Generation Sequencing and Whole Genome Selection in Aquaculture (pp. 21-33). Wiley Blackwell. https://doi.org/10.1002/9780470958964.ch2