Copper-Containing Catalytic Amyloids Promote Phosphoester Hydrolysis and Tandem Reactions

Zsófia Lengyel, Caroline M. Rufo, Yurii S. Moroz, Olga V. Makhlynets, Ivan V. Korendovych

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Self-assembly of short de novo designed peptides gives rise to catalytic amyloids capable of facilitating multiple chemical transformations. We show that catalytic amyloids can efficiently hydrolyze paraoxon, which is a widely used, highly toxic organophosphate pesticide. Moreover, these robust and inexpensive metal-containing materials can be easily deposited on various surfaces, producing catalytic flow devices. Finally, functional promiscuity of catalytic amyloids promotes tandem hydrolysis/oxidation reactions. High efficiency discovered in a very small library of peptides suggests an enormous potential for further improvement of catalytic properties, both in terms of catalytic efficiency and substrate scope.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalACS Catalysis
Issue number1
StatePublished - Jan 5 2018


  • cascade reaction
  • copper
  • paraoxon
  • peptides
  • self-assembly

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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