Copper- and palladium-catalyzed amidation reactions for the synthesis of substituted imidazo[4,5-c]pyridines

Robert J. Wilson, Adam J. Rosenberg, Lauren Kaminsky, Daniel A. Clark

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Imidazo[4,5-c]pyridines were synthesized in three steps utilizing a palladium-catalyzed amidation/cyclization strategy. N-Aryl substrates were synthesized using copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine. Complementary protocols for the selective chlorination of imidazo[4,5-c] pyridines at the C2 and C7 positions were also developed.

Original languageEnglish (US)
Pages (from-to)2203-2212
Number of pages10
JournalJournal of Organic Chemistry
Issue number5
StatePublished - Mar 7 2014


ASJC Scopus subject areas

  • Organic Chemistry

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