Imidazo[4,5-c]pyridines were synthesized in three steps utilizing a palladium-catalyzed amidation/cyclization strategy. N-Aryl substrates were synthesized using copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine. Complementary protocols for the selective chlorination of imidazo[4,5-c] pyridines at the C2 and C7 positions were also developed.
|Original language||English (US)|
|Number of pages||10|
|Journal||Journal of Organic Chemistry|
|State||Published - Mar 7 2014|
ASJC Scopus subject areas
- Organic Chemistry