Conjugate of Insulin and Vitamin B12 for Oral Delivery

Robert Doyle (Inventor)

Research output: Patent

Abstract

Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5′-hydroxyl group of the ribose moiety of α-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time.
Original languageEnglish (US)
Patent number8,883,723
StatePublished - Oct 2 2008

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Vitamin B 12
Insulin
Peptides
Glucagon-Like Peptide 1
Ribose
Therapeutics
Hydroxyl Radical
Gastrointestinal Tract
Ligands

Cite this

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