Conductive gelatin methacrylate-poly(aniline) hydrogel for cell encapsulation

Stephen W. Sawyer, Ping Dong, Sarah Venn, Andrew Ramos, David Quinn, Jason A. Horton, Pranav Soman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

New conductive hydrogels with superior biocompatibility continue to be developed in order to serve as bioactive scaffolds capable of modulating cellular functionality for tissue engineering applications. We developed an electrically conductive gelatin methacrylate-poly(aniline) (GelMA-PANi) hydrogel that is permissive of matrix mineralization by encapsulated osteoblast-like cells. Incorporation of PANi clusters within the GelMA matrix increases the electro-conductivity of the composite gel, while maintaining the osteoid-like soft mechanical properties that allows three-dimensional encapsulation of living cells. Viability of human osteogenic cells encapsulated within GelMA-PANi hydrogels was similar to that of GelMA. Cells within GelMA-PANi also demonstrated the capability of depositing mineral within the hydrogel matrix after being chemically induced for two weeks, although the total mineral content was lower as compared to GelMA. Additionally, we demonstrated that the GelMA-PANi-composite hydrogel could be printed in complex, user-defined geometries using digital projection stereolithography.

Original languageEnglish (US)
Article number015005
JournalBiomedical Physics and Engineering Express
Volume4
Issue number1
DOIs
StatePublished - Jan 2018

Keywords

  • cell encapsulation
  • gelatin methacrylate
  • polyaniline
  • stereolithography

ASJC Scopus subject areas

  • Nursing(all)

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