Computational and theoretical modeling of intermediate filament networks: Structure, mechanics and disease

Zhao Qin, Markus J. Buehler

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Intermediate filaments, in addition to microtubules and actin microfilaments, are one of the three major components of the cytoskeleton in eukaryotic cells. It was discovered during the recent decades that in most cells, intermediate filament proteins play key roles to reinforce cells subjected to large-deformation, and that they participate in signal transduction, and it was proposed that their nanomechanical properties are critical to perform those functions. However, it is still poorly understood how the nanoscopic structure, as well as the combination of chemical composition, molecular structure and interfacial properties of these protein molecules contribute to the biomechanical properties of filaments and filament networks. Here we review recent progress in computational and theoretical studies of the intermediate filaments network at various levels in the protein's structure. A multiple scale method is discussed, used to couple molecular modeling with atomistic detail to larger-scale material properties of the networked material. It is shown that a finer-trains-coarser methodology as discussed here provides a useful tool in understanding the biomechanical property and disease mechanism of intermediate filaments, coupling experiment and simulation. It further allows us to improve the understanding of associated disease mechanisms and lays the foundation for engineering the mechanical properties of biomaterials.

Original languageEnglish (US)
Pages (from-to)941-950
Number of pages10
JournalActa Mechanica Sinica/Lixue Xuebao
Volume28
Issue number4
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Disease mechanism
  • Intermediate filament network
  • Mechanics
  • Molecular mechanics
  • Multiple scale method
  • Nanoscopic structure

ASJC Scopus subject areas

  • Computational Mechanics
  • Mechanical Engineering

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