Compositions Comprising Vitamin B12 and Intrinsic Factor and Methods of use Thereof

Robert Doyle (Inventor)

Research output: Patent


A system for detecting cancer cells that targets the cubilin receptor for the vitamin B12 binding protein, intrinsic factor. A B12 conjugate and intrinsic factor is injected into the blood of a patient. The binding of intrinsic factor to cubilin will allow for receptor-mediated endocytosis and cellular internalization by cancerous cells, thereby allowing for detection via imaging or treatment.
Original languageEnglish (US)
StatePublished - Jul 14 2016


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