Complexes of the {ReVOX2}+ (X = Cl, Br) core with single amino acid chelate derivatives

Lihui Wei; John Babich; Jon Zubieta

doi:10.1016/j.ica.2005.01.018

Complexes of the {Re^VOX₂}⁺ (X = Cl, Br) core with single amino acid chelate derivatives

Lihui Wei, John Babich, Jon Zubieta

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The reactions of 1 equiv. of the ligand 3-(ethoxycarbonylmethyl-pyridin-2- ylmethyl-amino)-propionic acid methyl ester (2) with the Re(V) starting materials [ReOX₃(PPh₃)₂] (X = Cl, Br) in refluxing chloroform yielded the Re(V)-oxo dihalide complexes [ReOX ₂{(C₅H₄NCH₂)N(CH₂CO ₂)(C₂H₄CO₂CH₃)}] (X = Cl, 3; X = Br, 4). The complexes were characterized by elemental analysis, NMR and IR spectroscopy, cyclic voltammetry and X-ray crystallography. Complex 3 displays distorted octahedral coordination geometry with the tridentate ligand coordinating facially to the Re(V) center. The carboxylate oxygen atom occupies an axial site trans to the ReO bond. The two chlorine atoms consequently adopt a cis configuration.

Original language	English (US)
Pages (from-to)	2413-2421
Number of pages	9
Journal	Inorganica Chimica Acta
Volume	358
Issue number	7
DOIs	https://doi.org/10.1016/j.ica.2005.01.018
State	Published - Apr 15 2005

Keywords

Radiopharmaceutical design
Single amino acid chelates
{ReOX} core

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.ica.2005.01.018

Cite this

@article{60688587c9394256876f2ba5cc29e344,

title = "Complexes of the {ReVOX2}+ (X = Cl, Br) core with single amino acid chelate derivatives",

abstract = "The reactions of 1 equiv. of the ligand 3-(ethoxycarbonylmethyl-pyridin-2- ylmethyl-amino)-propionic acid methyl ester (2) with the Re(V) starting materials [ReOX3(PPh3)2] (X = Cl, Br) in refluxing chloroform yielded the Re(V)-oxo dihalide complexes [ReOX 2{(C5H4NCH2)N(CH2CO 2)(C2H4CO2CH3)}] (X = Cl, 3; X = Br, 4). The complexes were characterized by elemental analysis, NMR and IR spectroscopy, cyclic voltammetry and X-ray crystallography. Complex 3 displays distorted octahedral coordination geometry with the tridentate ligand coordinating facially to the Re(V) center. The carboxylate oxygen atom occupies an axial site trans to the ReO bond. The two chlorine atoms consequently adopt a cis configuration.",

keywords = "Radiopharmaceutical design, Single amino acid chelates, {ReOX} core",

author = "Lihui Wei and John Babich and Jon Zubieta",

note = "Funding Information: This work was supported by a grant from the National Institute of Health, National Institute of Allergy and Infection diseases, STTR 1R41 A1044080-01.",

year = "2005",

month = apr,

day = "15",

doi = "10.1016/j.ica.2005.01.018",

language = "English (US)",

volume = "358",

pages = "2413--2421",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier",

number = "7",

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TY - JOUR

T1 - Complexes of the {ReVOX2}+ (X = Cl, Br) core with single amino acid chelate derivatives

AU - Wei, Lihui

AU - Babich, John

AU - Zubieta, Jon

N1 - Funding Information: This work was supported by a grant from the National Institute of Health, National Institute of Allergy and Infection diseases, STTR 1R41 A1044080-01.

PY - 2005/4/15

Y1 - 2005/4/15

N2 - The reactions of 1 equiv. of the ligand 3-(ethoxycarbonylmethyl-pyridin-2- ylmethyl-amino)-propionic acid methyl ester (2) with the Re(V) starting materials [ReOX3(PPh3)2] (X = Cl, Br) in refluxing chloroform yielded the Re(V)-oxo dihalide complexes [ReOX 2{(C5H4NCH2)N(CH2CO 2)(C2H4CO2CH3)}] (X = Cl, 3; X = Br, 4). The complexes were characterized by elemental analysis, NMR and IR spectroscopy, cyclic voltammetry and X-ray crystallography. Complex 3 displays distorted octahedral coordination geometry with the tridentate ligand coordinating facially to the Re(V) center. The carboxylate oxygen atom occupies an axial site trans to the ReO bond. The two chlorine atoms consequently adopt a cis configuration.

AB - The reactions of 1 equiv. of the ligand 3-(ethoxycarbonylmethyl-pyridin-2- ylmethyl-amino)-propionic acid methyl ester (2) with the Re(V) starting materials [ReOX3(PPh3)2] (X = Cl, Br) in refluxing chloroform yielded the Re(V)-oxo dihalide complexes [ReOX 2{(C5H4NCH2)N(CH2CO 2)(C2H4CO2CH3)}] (X = Cl, 3; X = Br, 4). The complexes were characterized by elemental analysis, NMR and IR spectroscopy, cyclic voltammetry and X-ray crystallography. Complex 3 displays distorted octahedral coordination geometry with the tridentate ligand coordinating facially to the Re(V) center. The carboxylate oxygen atom occupies an axial site trans to the ReO bond. The two chlorine atoms consequently adopt a cis configuration.

KW - Radiopharmaceutical design

KW - Single amino acid chelates

KW - {ReOX} core

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JO - Inorganica Chimica Acta

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