Comparisons of the effects of guanethidine, 6-hydroxydopamine and diethyldithiocarbamate on retention of passive avoidance

Tibor Palfai, Thomas J. Walsh

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Depending on the dose levels, guanethidine and diethyldithiocarbamate produced time dependent amnesia for a one-trial passive avoidance task. 6-Hydroxydopamine given at any dose level or at any time interval before or after training did not result in retention deficits. The results were discussed in terms of the effects of these agents on peripheral biogenic amines and the possible role of these amines in memory formation.

Original languageEnglish (US)
Pages (from-to)805-809
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume13
Issue number6
DOIs
StatePublished - Dec 1980

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Keywords

  • Amnesia
  • Antiadrenergic
  • Biogenic amines
  • Drugs
  • Memory

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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