Comparison of the long-term cumulative effects of reserpine and syrosingopine on general activity

Tibor Palfai, Thomas J. Walsh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Reserpine, but not syrosingopine, produced a cumulative decrease in general motor activity when administered once every 10 days for a total of 8 drug treatments. The maximum depression of activity was evident following the second reserpine administration. Following a 30 day drug-free period animals previously treated with reserpine still exhibited decreased motor activity. The data suggest that chronic reserpine treatment may result in long term, and perhaps permanent behavioral effects.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume11
Issue number5
DOIs
StatePublished - Nov 1979

Keywords

  • Cumulative drug effects
  • Mice
  • Rauwolfia alkaloids
  • Reserpine
  • Spontaneous activity
  • Syrosingopine

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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