Comparison of the long-term cumulative effects of reserpine and syrosingopine on general activity

Tibor Palfai; Thomas J. Walsh

doi:10.1016/0091-3057(79)90046-7

Comparison of the long-term cumulative effects of reserpine and syrosingopine on general activity

Tibor Palfai, Thomas J. Walsh

Department of Psychology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Reserpine, but not syrosingopine, produced a cumulative decrease in general motor activity when administered once every 10 days for a total of 8 drug treatments. The maximum depression of activity was evident following the second reserpine administration. Following a 30 day drug-free period animals previously treated with reserpine still exhibited decreased motor activity. The data suggest that chronic reserpine treatment may result in long term, and perhaps permanent behavioral effects.

Original language	English (US)
Pages (from-to)	585-587
Number of pages	3
Journal	Pharmacology, Biochemistry and Behavior
Volume	11
Issue number	5
DOIs	https://doi.org/10.1016/0091-3057(79)90046-7
State	Published - Nov 1979

Keywords

Cumulative drug effects
Mice
Rauwolfia alkaloids
Reserpine
Spontaneous activity
Syrosingopine

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(79)90046-7

Cite this

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AB - Reserpine, but not syrosingopine, produced a cumulative decrease in general motor activity when administered once every 10 days for a total of 8 drug treatments. The maximum depression of activity was evident following the second reserpine administration. Following a 30 day drug-free period animals previously treated with reserpine still exhibited decreased motor activity. The data suggest that chronic reserpine treatment may result in long term, and perhaps permanent behavioral effects.

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KW - Mice

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KW - Reserpine

KW - Spontaneous activity

KW - Syrosingopine

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Comparison of the long-term cumulative effects of reserpine and syrosingopine on general activity

Abstract

Keywords

ASJC Scopus subject areas

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