Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: A preliminary study

Kevin M. Antshel, Stephen V. Faraone, Wanda Fremont, Michael C. Monuteaux, Wendy R. Kates, Alysa Doyle, Eric Mick, Joseph Biederman

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Objective: Background: Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD). Method: The authors compared youth with VCFS+ADHD (from the SUNY Upstate VCFS Research Program) to those with ADHD but not VCFS (from the Massachusetts General Hospital Longitudinal Family Studies of ADHD). Results: Children with VCFS+ADHD were more likely to be diagnosed with the inattentive subtype and differed from idiopathic ADHD in the frequency of several inattentive symptoms that appear linked to general cognitive functioning. After controlling for IQ differences, parents of children with VCFS+ADHD endorsed more thought and social problems on a rating checklist. Patterns of comorbidity also differed between the two groups of children with ADHD: Children with idiopathic ADHD had higher rates of comorbid major depression and disruptive behavior disorders. Conclusion: Children with VCFS+ADHD may have a different profile of ADHD symptoms and comorbidity when compared to children with idiopathic ADHD. (J. of Att. Dis. 2007; 11(1) 64-73)

Original languageEnglish (US)
Pages (from-to)64-73
Number of pages10
JournalJournal of Attention Disorders
Issue number1
StatePublished - Aug 2007
Externally publishedYes


  • ADHD
  • Mental retardation
  • Velocardiofacial syndrome (VCFS)

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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