Abstract
Overturn as produced in goldfish by various concentrations of ethanol and/or sodium pentobarbital was studied in tromethamine‐buffered solutions at pH 7.1 and a solution temperature of 23°. The results indicate that ethanol and pentobarbital interact in an additive manner to produce overturn. Tolerance or cross‐tolerance was not observed, with one exception, when fish maintained in low concentrations of ethanol or pentobarbital for 48 hr. were tested against two concentrations of the same drug or the opposite drug. Determination of the ratio of death time/overturn time for the two agents indicates a greater margin of safety for ethanol than for pentobarbital.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1401-1403 |
| Number of pages | 3 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 61 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1972 |
Keywords
- CNS depression—ethanol and pentobarbital in goldfish
- Ethanol depressant activity—goldfish overturn, compared to pentobarbital
- Goldfish—comparative depressant (overturn) activity of ethanol and pentobarbital in tromethamine
- Pentobarbital, sodium, depressant activity—goldfish overturn, compared to ethanol
ASJC Scopus subject areas
- Pharmaceutical Science