Comparative Antitumor Studies on Platinum(II) and Platinum(IV) Complexes Containing 1,2-Diaminocyclohexane

Jean F. Vollano, Salaam Al-baker, James C. Dabrowiak, John E. Schurig

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

The synthesis and characterization of a group of platinum(IV) compounds containing the various isomeric forms of 1,2-diaminocyclohexane (DACH) are described. Antitumor tests with the new complexes, as well as with other platinum(II) compounds containing the DACH ligand, revealed that trans,cis-PtIV(SS-DACH)(OH)2Cl2, 7, is more active than its mirror image, trans,cis-PtIV(RR-DACHH)(OH)2Cl, 6, against L1210 leukemia implanted in mice. However, activity is dependent on the tumor model, and against B16 melanoma implanted in mice, the activities of the two enantiomers are reversed, with 6 being more active than 7. The results of the tests are discussed in light of the mechanism by which Pt(IV) compounds are believed to express their antitumor effects.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalJournal of Medicinal Chemistry
Volume30
Issue number4
DOIs
StatePublished - Apr 1 1987

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Fingerprint Dive into the research topics of 'Comparative Antitumor Studies on Platinum(II) and Platinum(IV) Complexes Containing 1,2-Diaminocyclohexane'. Together they form a unique fingerprint.

Cite this