Combining In Silico Design and Biomimetic Assembly: A New Approach for Developing High-Performance Dynamic Responsive Bio-Nanomaterials

Shengjie Ling, Kai Jin, Zhao Qin, Chunmei Li, Ke Zheng, Yanyan Zhao, Qi Wang, David L. Kaplan, Markus J. Buehler

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Major challenge remains in the design and fabrication of artificial hierarchical materials that mimic the structural and functional features of these natural materials. Here, a novel biomimetic strategy to assemble hierarchical materials from biological nanobuilding blocks is demonstrated. The constituents and structures of the materials are designed by multiscale modeling and then experimentally constructed by multiscale self-assembly. The resultant materials that consist of silk nanofibrils (SNFs), hydroxyapatite (HAP), and chitin nanofibrils (CNFs) show nacre-like structures with mechanical strength and toughness better than most natural nacre and nacre-like nanocomposites. In addition, these SNF/HAP:CNF nanocomposites can be programmed into “grab-and-release” actuators due to the gradient structure of the nanocomposites as well as the high water sensitivity of each of the components, and thusshow potential applications in the design of novel third-generation biomaterials for potential clinical applications. In addition, this “in silico design and biomimetic assembly” route represents a rational, low-cost, and efficient strategy for the design and preparation of robust, hierarchical, and functional nanomaterials to meet a variety of application requirements in bio-nanotechnologies.

Original languageEnglish (US)
Article number1802306
JournalAdvanced Materials
Volume30
Issue number43
DOIs
StatePublished - Oct 25 2018

Keywords

  • biomimetic materials
  • dynamic responsive materials
  • modeling design
  • self-assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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