TY - JOUR
T1 - Cold Plasma Reticulation of Shape Memory Embolic Tissue Scaffolds
AU - Nash, Landon D.
AU - Docherty, Nicole C.
AU - Monroe, Mary Beth B.
AU - Ezell, Kendal P.
AU - Carrow, James K.
AU - Hasan, Sayyeda M.
AU - Gaharwar, Akhilesh K.
AU - Maitland, Duncan J.
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Polyurethane shape memory polymer (SMP) foams are proposed for use as thrombogenic scaffolds to improve the treatment of vascular defects, such as cerebral aneurysms. However, gas blown SMP foams inherently have membranes between pores, which can limit their performance as embolic tissue scaffolds. Reticulation, or the removal of membranes between adjacent foam pores, is advantageous for improving device performance by increasing blood permeability and cellular infiltration. This work characterizes the effects of cold gas plasma reticulation processes on bulk polyurethane SMP films and foams. Plasma-induced changes on material properties are characterized using scanning electron microscopy, uniaxial tensile testing, goniometry, and free strain recovery experiments. Device specific performance is characterized in terms of permeability, platelet attachment, and cell–material interactions. Overall, plasma reticulated SMP scaffolds show promise as embolic tissue scaffolds due to increased bulk permeability, retained thrombogenicity, and favorable cell–material interactions. (Figure presented.).
AB - Polyurethane shape memory polymer (SMP) foams are proposed for use as thrombogenic scaffolds to improve the treatment of vascular defects, such as cerebral aneurysms. However, gas blown SMP foams inherently have membranes between pores, which can limit their performance as embolic tissue scaffolds. Reticulation, or the removal of membranes between adjacent foam pores, is advantageous for improving device performance by increasing blood permeability and cellular infiltration. This work characterizes the effects of cold gas plasma reticulation processes on bulk polyurethane SMP films and foams. Plasma-induced changes on material properties are characterized using scanning electron microscopy, uniaxial tensile testing, goniometry, and free strain recovery experiments. Device specific performance is characterized in terms of permeability, platelet attachment, and cell–material interactions. Overall, plasma reticulated SMP scaffolds show promise as embolic tissue scaffolds due to increased bulk permeability, retained thrombogenicity, and favorable cell–material interactions. (Figure presented.).
KW - foam reticulation
KW - plasma surface modification
KW - shape memory polymers
UR - http://www.scopus.com/inward/record.url?scp=84983608382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983608382&partnerID=8YFLogxK
U2 - 10.1002/marc.201600268
DO - 10.1002/marc.201600268
M3 - Article
C2 - 27568830
AN - SCOPUS:84983608382
SN - 1022-1336
VL - 37
SP - 1945
EP - 1951
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 23
ER -