Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Amanda E. Hoffman, Michelle DeStefano, Carolyn Shoen, Krishnamoorthy Gopinath, Digby F. Warner, Michael Cynamon, Robert P. Doyle

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacteriumtuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume70
DOIs
StatePublished - Jan 1 2013

Keywords

  • Bacteriocidal
  • Cobalt
  • Copper
  • MDR-TB
  • Pyrophosphate
  • TB

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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