Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis

Amanda E. Hoffman, Michelle DeStefano, Carolyn Shoen, Krishnamoorthy Gopinath, Digby F. Warner, Michael Cynamon, Robert Patrick Doyle

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Tuberculosis (TB) causes up to 10 million incident cases worldwide per annum. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are leading factors in the resurgence of TB cases and the need to produce new agents to combat such infection. Herein, we describe Co(II) and Cu(II) metal based complexes that feature the pyrophosphate ligand with notable selectivity and marked potency against Mycobacteriumtuberculosis, including MDR strains. Such complexes are confirmed to be bacteriocidal and not affected by efflux inhibitors. Finally, while susceptibility to copper has recently been established for M. tuberculosis, the greater efficacy of cobalt observed herein is of considerable note and in line with the discovery of a copper metallothionein in M. tuberculosis.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalEuropean Journal of Medicinal Chemistry
Volume70
DOIs
StatePublished - 2013

Fingerprint

Mycobacterium
Tuberculosis
Cobalt
Copper
Metals
Ligands
Coordination Complexes
Pharmaceutical Preparations
diphosphoric acid
Infection
copper thionein

Keywords

  • Bacteriocidal
  • Cobalt
  • Copper
  • MDR-TB
  • Pyrophosphate
  • TB

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis. / Hoffman, Amanda E.; DeStefano, Michelle; Shoen, Carolyn; Gopinath, Krishnamoorthy; Warner, Digby F.; Cynamon, Michael; Doyle, Robert Patrick.

In: European Journal of Medicinal Chemistry, Vol. 70, 2013, p. 589-593.

Research output: Contribution to journalArticle

Hoffman, Amanda E. ; DeStefano, Michelle ; Shoen, Carolyn ; Gopinath, Krishnamoorthy ; Warner, Digby F. ; Cynamon, Michael ; Doyle, Robert Patrick. / Co(II) and Cu(II) pyrophosphate complexes have selectivity and potency against Mycobacteria including Mycobacteriumtuberculosis. In: European Journal of Medicinal Chemistry. 2013 ; Vol. 70. pp. 589-593.
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AU - Warner, Digby F.

AU - Cynamon, Michael

AU - Doyle, Robert Patrick

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