TY - JOUR
T1 - Cognitive and Psychiatric Predictors to Psychosis in Velocardiofacial Syndrome
T2 - A 3-Year Follow-Up Study
AU - Antshel, Kevin M.
AU - Shprintzen, Robert
AU - Fremont, Wanda
AU - Higgins, Anne Marie
AU - Faraone, Stephen V.
AU - Kates, Wendy R.
N1 - Funding Information:
This work was funded by National Institute of Mental Health grants MH64824 and MH65481 to Wendy Kates.
PY - 2010/4
Y1 - 2010/4
N2 - Objective: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). Method: A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points. Results: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test. Conclusions: Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention.
AB - Objective: To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS). Method: A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points. Results: Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test. Conclusions: Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention.
KW - 22q11 deletion syndrome
KW - cognition
KW - longitudinal
KW - psychosis
KW - velocardiofacial syndrome (VCFS)
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U2 - 10.1097/00004583-201004000-00008
DO - 10.1097/00004583-201004000-00008
M3 - Article
C2 - 20410726
AN - SCOPUS:77949656899
SN - 0890-8567
VL - 49
SP - 333
EP - 344
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 4
ER -