Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity

Corey R. Centerwall, Jerry Goodisman, Deborah J. Kerwood, James C. Dabrowiak

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

Original languageEnglish (US)
Pages (from-to)12768-12769
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number37
DOIs
StatePublished - Sep 21 2005

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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