Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity

Corey R. Centerwall; Jerry Goodisman; Deborah J. Kerwood; James C. Dabrowiak

doi:10.1021/ja053353c

Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity

Corey R. Centerwall, Jerry Goodisman, Deborah J. Kerwood, James C. Dabrowiak

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

Original language	English (US)
Pages (from-to)	12768-12769
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	37
DOIs	https://doi.org/10.1021/ja053353c
State	Published - Sep 21 2005

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja053353c

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title = "Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity",

abstract = "The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.",

author = "Centerwall, {Corey R.} and Jerry Goodisman and Kerwood, {Deborah J.} and Dabrowiak, {James C.}",

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Y1 - 2005/9/21

N2 - The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

AB - The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.

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Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity

Abstract

ASJC Scopus subject areas

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