Chronic Wound Dressings Based on Collagen-Mimetic Proteins

Stacy Cereceres, Tyler Touchet, Mary Beth Browning, Clayton Smith, Jose Rivera, Magnus Höök, Canaan Whitfield-Cargile, Brooke Russell, Elizabeth Cosgriff-Hernandez

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Objective: Chronic wounds are projected to reach epidemic proportions due to the aging population and the increasing incidence of diabetes. There is a strong clinical need for an improved wound dressing that can balance wound moisture, promote cell migration and proliferation, and degrade at an appropriate rate to minimize the need for dressing changes. Approach: To this end, we have developed a bioactive, hydrogel microsphere wound dressing that incorporates a collagen-mimetic protein, Scl2GFPGER, to promote active wound healing. A redesigned Scl2GFPGER, engineered collagen (eColGFPGER), was created to reduce steric hindrance of integrin-binding motifs and increase overall stability of the triple helical backbone, thereby resulting in increased cell adhesion to substrates. Results: This study demonstrates the successful modification of the Scl2GFPGER protein to eColGFPGER, which displayed enhanced stability and integrin interactions. Fabrication of hydrogel microspheres provided a matrix with adaptive moisture technology, and degradation rates have potential for use in human wounds. Innovation: This collagen-mimetic wound dressing was designed to permit controlled modulation of cellular interactions and degradation rate without impact on other physical properties. Its fabrication into uniform hydrogel microspheres provides a bioactive dressing that can readily conform to irregular wounds. Conclusion: Overall, this new eColGFPGER shows strong promise in the generation of bioactive hydrogels for wound healing as well as a variety of tissue scaffolds.

Original languageEnglish (US)
Pages (from-to)444-456
Number of pages13
JournalAdvances in Wound Care
Volume4
Issue number8
DOIs
StatePublished - Aug 1 2015

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

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    Cereceres, S., Touchet, T., Browning, M. B., Smith, C., Rivera, J., Höök, M., Whitfield-Cargile, C., Russell, B., & Cosgriff-Hernandez, E. (2015). Chronic Wound Dressings Based on Collagen-Mimetic Proteins. Advances in Wound Care, 4(8), 444-456. https://doi.org/10.1089/wound.2014.0614