Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers

David Mayett, Nicholas Bitten, Moumita Das, Jennifer M Schwarz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model composed of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading from the interacting motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force and, therefore, posit that active rupture, or rupture via active forces, is a mechanosensitive means to regulate dynamics between cells. Since the parameters in the model differentiate between N- and E-cadherins, we make predictions for the interactions between a placodelike cell and a neural crestlike cell in a microchannel as well as discuss how our results inform chase-and-run dynamics found in a group of placode cells interacting with a group of neural crest cells. In particular, an argument was made in the latter case that the feedback between cadherins and cell-substrate interaction via integrins was necessary to obtain the chase-and-run behavior. Based on our two-cell results, we argue that this feedback accentuates, but is not necessary for, the chase-and-run behavior.

Original languageEnglish (US)
Article number032407
JournalPhysical Review E
Volume96
Issue number3
DOIs
StatePublished - Sep 11 2017

Fingerprint

Cell Motility
locomotion
Rupture
Dimer
dimers
Cell
cells
Interaction
Integrin
interactions
Cell Migration
Morphogenesis
Metastasis
Necessary
Microchannel
thresholds
One-dimensional Model
Differentiate
metastasis
microchannels

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers. / Mayett, David; Bitten, Nicholas; Das, Moumita; Schwarz, Jennifer M.

In: Physical Review E, Vol. 96, No. 3, 032407, 11.09.2017.

Research output: Contribution to journalArticle

@article{def6ec59db864405b40ea899fe5709a9,
title = "Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers",
abstract = "Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model composed of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading from the interacting motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force and, therefore, posit that active rupture, or rupture via active forces, is a mechanosensitive means to regulate dynamics between cells. Since the parameters in the model differentiate between N- and E-cadherins, we make predictions for the interactions between a placodelike cell and a neural crestlike cell in a microchannel as well as discuss how our results inform chase-and-run dynamics found in a group of placode cells interacting with a group of neural crest cells. In particular, an argument was made in the latter case that the feedback between cadherins and cell-substrate interaction via integrins was necessary to obtain the chase-and-run behavior. Based on our two-cell results, we argue that this feedback accentuates, but is not necessary for, the chase-and-run behavior.",
author = "David Mayett and Nicholas Bitten and Moumita Das and Schwarz, {Jennifer M}",
year = "2017",
month = "9",
day = "11",
doi = "10.1103/PhysRevE.96.032407",
language = "English (US)",
volume = "96",
journal = "Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics",
issn = "1063-651X",
publisher = "American Physical Society",
number = "3",

}

TY - JOUR

T1 - Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers

AU - Mayett, David

AU - Bitten, Nicholas

AU - Das, Moumita

AU - Schwarz, Jennifer M

PY - 2017/9/11

Y1 - 2017/9/11

N2 - Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model composed of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading from the interacting motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force and, therefore, posit that active rupture, or rupture via active forces, is a mechanosensitive means to regulate dynamics between cells. Since the parameters in the model differentiate between N- and E-cadherins, we make predictions for the interactions between a placodelike cell and a neural crestlike cell in a microchannel as well as discuss how our results inform chase-and-run dynamics found in a group of placode cells interacting with a group of neural crest cells. In particular, an argument was made in the latter case that the feedback between cadherins and cell-substrate interaction via integrins was necessary to obtain the chase-and-run behavior. Based on our two-cell results, we argue that this feedback accentuates, but is not necessary for, the chase-and-run behavior.

AB - Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model composed of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading from the interacting motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force and, therefore, posit that active rupture, or rupture via active forces, is a mechanosensitive means to regulate dynamics between cells. Since the parameters in the model differentiate between N- and E-cadherins, we make predictions for the interactions between a placodelike cell and a neural crestlike cell in a microchannel as well as discuss how our results inform chase-and-run dynamics found in a group of placode cells interacting with a group of neural crest cells. In particular, an argument was made in the latter case that the feedback between cadherins and cell-substrate interaction via integrins was necessary to obtain the chase-and-run behavior. Based on our two-cell results, we argue that this feedback accentuates, but is not necessary for, the chase-and-run behavior.

UR - http://www.scopus.com/inward/record.url?scp=85029862452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029862452&partnerID=8YFLogxK

U2 - 10.1103/PhysRevE.96.032407

DO - 10.1103/PhysRevE.96.032407

M3 - Article

C2 - 29346935

AN - SCOPUS:85029862452

VL - 96

JO - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics

JF - Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics

SN - 1063-651X

IS - 3

M1 - 032407

ER -