@inproceedings{408026544f884cb6a32935d3a71b7469,
title = "Characterizing stiffness of sickle cell trait red blood cells under strenuous exercise conditions",
abstract = "The risk of vaso-occlusion events of sickle cell trait (SCT) athletes were speculatively ascribed to SCT red blood cell (RBC) stiffening during strenuous exercise. However, it is unknown what microenvironmental changes could induce the stiffening. To address this question, we measured the mechanical property changes of SCT RBCs under deoxygenated and acidic environments, two typical conditions present in the circulation of athletes when undertaking strenuous exercise. The results reveal that SCT RBCs are inherently stiffer than control RBCs, and lowering pH further stiffens the SCT cells. Furthermore, deoxygenation was found not to cause the stiffness of SCT RBCs to change.",
keywords = "Microfluidics, Red blood cells, Shear modulus, Sickle cell trait, Stiffening",
author = "Z. Xu and Y. Zheng and C. Wang and Y. Sun",
note = "Funding Information: Financial support from NSERC is acknowledged.; 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 ; Conference date: 09-10-2016 Through 13-10-2016",
year = "2016",
language = "English (US)",
series = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
publisher = "Chemical and Biological Microsystems Society",
pages = "1611--1612",
booktitle = "20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016",
}