Characterization of red blood cell deformability change during blood storage

Yi Zheng, Jun Chen, Tony Cui, Nadine Shehata, Chen Wang, Yu Sun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.

Original languageEnglish (US)
Title of host publicationMEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages833-836
Number of pages4
ISBN (Print)9781479935086
DOIs
StatePublished - 2014
Externally publishedYes
Event27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States
Duration: Jan 26 2014Jan 30 2014

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Conference

Conference27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Country/TerritoryUnited States
CitySan Francisco, CA
Period1/26/141/30/14

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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