TY - GEN
T1 - Characterization of red blood cell deformability change during blood storage
AU - Zheng, Yi
AU - Chen, Jun
AU - Cui, Tony
AU - Shehata, Nadine
AU - Wang, Chen
AU - Sun, Yu
PY - 2014
Y1 - 2014
N2 - Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.
AB - Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.
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U2 - 10.1109/MEMSYS.2014.6765770
DO - 10.1109/MEMSYS.2014.6765770
M3 - Conference contribution
AN - SCOPUS:84899026495
SN - 9781479935086
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 833
EP - 836
BT - MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Y2 - 26 January 2014 through 30 January 2014
ER -