Characterization of red blood cell deformability change during blood storage

Yi Zheng; Jun Chen; Tony Cui; Nadine Shehata; Chen Wang; Yu Sun

doi:10.1109/MEMSYS.2014.6765770

Characterization of red blood cell deformability change during blood storage

Yi Zheng, Jun Chen, Tony Cui, Nadine Shehata, Chen Wang, Yu Sun

Research output: Chapter in Book/Entry/Poem › Conference contribution

1 Scopus citations

Abstract

Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.

Original language	English (US)
Title of host publication	MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	833-836
Number of pages	4
ISBN (Print)	9781479935086
DOIs	https://doi.org/10.1109/MEMSYS.2014.6765770
State	Published - 2014
Externally published	Yes
Event	27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014 - San Francisco, CA, United States Duration: Jan 26 2014 → Jan 30 2014

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)	1084-6999

Conference

Conference	27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014
Country/Territory	United States
City	San Francisco, CA
Period	1/26/14 → 1/30/14

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMSYS.2014.6765770

Cite this

Zheng, Y., Chen, J., Cui, T., Shehata, N., Wang, C., & Sun, Y. (2014). Characterization of red blood cell deformability change during blood storage. In MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems (pp. 833-836). Article 6765770 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2014.6765770

Characterization of red blood cell deformability change during blood storage. / Zheng, Yi; Chen, Jun; Cui, Tony et al.
MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc., 2014. p. 833-836 6765770 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

Research output: Chapter in Book/Entry/Poem › Conference contribution

Zheng, Y, Chen, J, Cui, T, Shehata, N, Wang, C & Sun, Y 2014, Characterization of red blood cell deformability change during blood storage. in MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems., 6765770, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), Institute of Electrical and Electronics Engineers Inc., pp. 833-836, 27th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2014, San Francisco, CA, United States, 1/26/14. https://doi.org/10.1109/MEMSYS.2014.6765770

Zheng Y, Chen J, Cui T, Shehata N, Wang C, Sun Y. Characterization of red blood cell deformability change during blood storage. In MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc. 2014. p. 833-836. 6765770. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2014.6765770

Zheng, Yi ; Chen, Jun ; Cui, Tony et al. / Characterization of red blood cell deformability change during blood storage. MEMS 2014 - 27th IEEE International Conference on Micro Electro Mechanical Systems. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 833-836 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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title = "Characterization of red blood cell deformability change during blood storage",

abstract = "Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.",

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AB - Stored red blood cells (RBCs) show progressive deformability change during blood banking/storage. Their deformability change over an 8 weeks' storage period was measured in this work using a microfluidic device and highspeed imaging. Multiple parameters including deformation index (DI), time constant (shape recovery rate), and RBC circularity were quantified. Compared to previous RBC deformability studies reported in the literature, our results include a significantly higher number of cells (>1,000 cells/sample vs. a few to tens of cells/sample) and, for the first time, reveal deformation changes of stored RBCs when they travel through human-capillary-like microchannels. The correlation between deformability and morphology of stored RBCs is also presented.

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Characterization of red blood cell deformability change during blood storage

Abstract

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