Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO

Genevieve M. Halpenny, Rachel C. Steinhardt, Krystle A. Okialda, Pradip K. Mascharak

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

A light-activated NO donor, [Mn(PaPy3)(NO)]ClO4 (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1ax • HG and 1ax • HG MB have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1ax • HGMB could be used as wound dressings that deliver NO under controlled conditions.

Original languageEnglish (US)
Pages (from-to)2353-2360
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Volume20
Issue number11
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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