TY - JOUR
T1 - Characterization of pHEMA-based hydrogels that exhibit light-induced bactericidal effect via release of NO
AU - Halpenny, Genevieve M.
AU - Steinhardt, Rachel C.
AU - Okialda, Krystle A.
AU - Mascharak, Pradip K.
N1 - Funding Information:
Acknowledgments Financial support from the NSF Grant CHE-0553405 is gratefully acknowledged. G.M.H. and K.A.O. were supported by NIH IMSD Grant No. GM58903.
PY - 2009/11
Y1 - 2009/11
N2 - A light-activated NO donor, [Mn(PaPy3)(NO)]ClO4 (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1ax • HG and 1ax • HG MB have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1ax • HGMB could be used as wound dressings that deliver NO under controlled conditions.
AB - A light-activated NO donor, [Mn(PaPy3)(NO)]ClO4 (1a), has been incorporated into HEMA-based polymer hydrogel and the nitrosyl-polymer conjugate materials 1ax • HG and 1ax • HG MB have been characterized. The NO releasing properties and antibacterial capabilities of these materials in conjunction with growth attenuators such as hydrogen peroxide and methylene blue (MB) are reported. Since the nitrosyl releases NO only upon exposure to light, materials like 1ax • HGMB could be used as wound dressings that deliver NO under controlled conditions.
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U2 - 10.1007/s10856-009-3795-0
DO - 10.1007/s10856-009-3795-0
M3 - Article
C2 - 19554428
AN - SCOPUS:70450286199
SN - 0957-4530
VL - 20
SP - 2353
EP - 2360
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
IS - 11
ER -