Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV

Kathleen A. McGinnis; Janet P. Tate; Kendall J. Bryant; Amy C. Justice; Patrick G. O’Connor; Maria C. Rodriguez-Barradas; Stephen Crystal; Christopher J. Cutter; Nathan B. Hansen; Stephen A. Maisto; Vincent C. Marconi; Emily C. Williams; Robert L. Cook; Adam J. Gordon; Kirsha S. Gordon; Oghenowede Eyawo; E. Jennifer Edelman; David A. Fiellin

doi:10.1007/s10461-021-03438-y

Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV

Kathleen A. McGinnis, Janet P. Tate, Kendall J. Bryant, Amy C. Justice, Patrick G. O’Connor, Maria C. Rodriguez-Barradas, Stephen Crystal, Christopher J. Cutter, Nathan B. Hansen, Stephen A. Maisto, Vincent C. Marconi, Emily C. Williams, Robert L. Cook, Adam J. Gordon, Kirsha S. Gordon, Oghenowede Eyawo, E. Jennifer Edelman, David A. Fiellin

Department of Psychology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the biomarker phosphatidylethanol (PEth) and compared changes in TLFB and PEth among persons with HIV (PWH) using secondary data from randomized trials. We calculated operating characteristics and agreement between TLFB (> 1 and > 2 average drinks/day), AUDIT-C ≥ 4 and PEth ≥ 20 among 275 men with HIV. Median age was 57 years, 80% were African-American; and 17% white. Sixty-eight percent had PEth ≥ 20, 46% reported > 2 average drinks/day on TLFB, 61% reported > 1 average drinks/day on TLFB, and 72% had an AUDIT-C ≥ 4. Relative to PEth, sensitivity for AUDIT-C ≥ 4 was 84% (kappa = 0.36), and for TLFB > 1 average drink/day was 76% (kappa = 0.44). Change in alcohol use appeared greater using TLFB measures than PEth. Strategies to robustly assess alcohol use in PWH may require both self-report and biomarkers.

Original language	English (US)
Pages (from-to)	786-794
Number of pages	9
Journal	AIDS and Behavior
Volume	26
Issue number	3
DOIs	https://doi.org/10.1007/s10461-021-03438-y
State	Published - Mar 2022

Keywords

Alcohol consumption
HIV infection
Phosphatidylethanolamine

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-021-03438-y

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McGinnis, K. A., Tate, J. P., Bryant, K. J., Justice, A. C., O’Connor, P. G., Rodriguez-Barradas, M. C., Crystal, S., Cutter, C. J., Hansen, N. B., Maisto, S. A., Marconi, V. C., Williams, E. C., Cook, R. L., Gordon, A. J., Gordon, K. S., Eyawo, O., Edelman, E. J., & Fiellin, D. A. (2022). Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV. AIDS and Behavior, 26(3), 786-794. https://doi.org/10.1007/s10461-021-03438-y

McGinnis, KA, Tate, JP, Bryant, KJ, Justice, AC, O’Connor, PG, Rodriguez-Barradas, MC, Crystal, S, Cutter, CJ, Hansen, NB, Maisto, SA, Marconi, VC, Williams, EC, Cook, RL, Gordon, AJ, Gordon, KS, Eyawo, O, Edelman, EJ & Fiellin, DA 2022, 'Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV', AIDS and Behavior, vol. 26, no. 3, pp. 786-794. https://doi.org/10.1007/s10461-021-03438-y

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title = "Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV",

abstract = "The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the biomarker phosphatidylethanol (PEth) and compared changes in TLFB and PEth among persons with HIV (PWH) using secondary data from randomized trials. We calculated operating characteristics and agreement between TLFB (> 1 and > 2 average drinks/day), AUDIT-C ≥ 4 and PEth ≥ 20 among 275 men with HIV. Median age was 57 years, 80% were African-American; and 17% white. Sixty-eight percent had PEth ≥ 20, 46% reported > 2 average drinks/day on TLFB, 61% reported > 1 average drinks/day on TLFB, and 72% had an AUDIT-C ≥ 4. Relative to PEth, sensitivity for AUDIT-C ≥ 4 was 84% (kappa = 0.36), and for TLFB > 1 average drink/day was 76% (kappa = 0.44). Change in alcohol use appeared greater using TLFB measures than PEth. Strategies to robustly assess alcohol use in PWH may require both self-report and biomarkers.",

keywords = "Alcohol consumption, HIV infection, Phosphatidylethanolamine",

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note = "Publisher Copyright: {\textcopyright} 2021, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.",

year = "2022",

month = mar,

doi = "10.1007/s10461-021-03438-y",

language = "English (US)",

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AU - McGinnis, Kathleen A.

AU - Tate, Janet P.

AU - Bryant, Kendall J.

AU - Justice, Amy C.

AU - O’Connor, Patrick G.

AU - Rodriguez-Barradas, Maria C.

AU - Crystal, Stephen

AU - Cutter, Christopher J.

AU - Hansen, Nathan B.

AU - Maisto, Stephen A.

AU - Marconi, Vincent C.

AU - Williams, Emily C.

AU - Cook, Robert L.

AU - Gordon, Adam J.

AU - Gordon, Kirsha S.

AU - Eyawo, Oghenowede

AU - Edelman, E. Jennifer

AU - Fiellin, David A.

PY - 2022/3

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N2 - The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the biomarker phosphatidylethanol (PEth) and compared changes in TLFB and PEth among persons with HIV (PWH) using secondary data from randomized trials. We calculated operating characteristics and agreement between TLFB (> 1 and > 2 average drinks/day), AUDIT-C ≥ 4 and PEth ≥ 20 among 275 men with HIV. Median age was 57 years, 80% were African-American; and 17% white. Sixty-eight percent had PEth ≥ 20, 46% reported > 2 average drinks/day on TLFB, 61% reported > 1 average drinks/day on TLFB, and 72% had an AUDIT-C ≥ 4. Relative to PEth, sensitivity for AUDIT-C ≥ 4 was 84% (kappa = 0.36), and for TLFB > 1 average drink/day was 76% (kappa = 0.44). Change in alcohol use appeared greater using TLFB measures than PEth. Strategies to robustly assess alcohol use in PWH may require both self-report and biomarkers.

AB - The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the biomarker phosphatidylethanol (PEth) and compared changes in TLFB and PEth among persons with HIV (PWH) using secondary data from randomized trials. We calculated operating characteristics and agreement between TLFB (> 1 and > 2 average drinks/day), AUDIT-C ≥ 4 and PEth ≥ 20 among 275 men with HIV. Median age was 57 years, 80% were African-American; and 17% white. Sixty-eight percent had PEth ≥ 20, 46% reported > 2 average drinks/day on TLFB, 61% reported > 1 average drinks/day on TLFB, and 72% had an AUDIT-C ≥ 4. Relative to PEth, sensitivity for AUDIT-C ≥ 4 was 84% (kappa = 0.36), and for TLFB > 1 average drink/day was 76% (kappa = 0.44). Change in alcohol use appeared greater using TLFB measures than PEth. Strategies to robustly assess alcohol use in PWH may require both self-report and biomarkers.

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KW - HIV infection

KW - Phosphatidylethanolamine

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Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV

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