Challenges in the diagnosis of magnesium status

Jayme L. Workinger, Robert Patrick Doyle, Jonathan Bortz

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Magnesium is a critical mineral in the human body and is involved in ~80% of known metabolic functions. It is currently estimated that 60% of adults do not achieve the average dietary intake (ADI) and 45% of Americans are magnesium deficient, a condition associated with disease states like hypertension, diabetes, and neurological disorders, to name a few. Magnesium deficiency can be attributed to common dietary practices, medications, and farming techniques, along with estimates that the mineral content of vegetables has declined by as much as 80–90% in the last 100 years. However, despite this mineral’s importance, it is poorly understood from several standpoints, not the least of which is its unique mechanism of absorption and sensitive compartmental handling in the body, making the determination of magnesium status difficult. The reliance on several popular sample assays has contributed to a great deal of confusion in the literature. This review will discuss causes of magnesium deficiency, absorption, handling, and compartmentalization in the body, highlighting the challenges this creates in determining magnesium status in both clinical and research settings.

Original languageEnglish (US)
Article number1202
JournalNutrients
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2018

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Magnesium
magnesium
Magnesium Deficiency
Minerals
Nervous System Diseases
Agriculture
Human Body
Vegetables
minerals
Names
nervous system diseases
Hypertension
hypertension
drug therapy
mineral content
diabetes
food intake
farming systems
vegetables
Research

Keywords

  • Magnesium
  • Magnesium absorption
  • Magnesium assays
  • Magnesium deficiency
  • Magnesium sampling
  • Magnesium status

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Challenges in the diagnosis of magnesium status. / Workinger, Jayme L.; Doyle, Robert Patrick; Bortz, Jonathan.

In: Nutrients, Vol. 10, No. 9, 1202, 01.09.2018.

Research output: Contribution to journalReview article

Workinger, Jayme L. ; Doyle, Robert Patrick ; Bortz, Jonathan. / Challenges in the diagnosis of magnesium status. In: Nutrients. 2018 ; Vol. 10, No. 9.
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