Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy

M. Haeri, J. L. Gilbert

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Surface potential of biomedical implants can significantly alter the behavior of the surrounding cells including cell morphology and viability. In this work, the effect of changing the potenial of a CoCr biomedical alloy on the morphology and viability of murine preosteblast cells (MC3T3) was studied. CoCr samples were polarized to cathodic and anodic voltages ranging from -1000 to +500 mv. The morphology and viability were studied using scanning electron microscopy and Live-dead assay techniques, respectively. It was found that voltage significantly influences the cellular response and there exists a voltage viability range, outside of which cells will not be viable. Both anodic (greater than 500 mV) and cathodic (more negative than -100 mV) voltage extremes induced cell death on CoCr surfaces.

Original languageEnglish (US)
Title of host publicationMedical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference
Pages181-185
Number of pages5
StatePublished - Aug 26 2010
Event5th Materials and Processes for Medical Devices Conference, MPMD - Minneapolis, MN, United States
Duration: Aug 10 2009Aug 12 2009

Publication series

NameMedical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference

Other

Other5th Materials and Processes for Medical Devices Conference, MPMD
CountryUnited States
CityMinneapolis, MN
Period8/10/098/12/09

ASJC Scopus subject areas

  • Biomedical Engineering
  • Materials Chemistry

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  • Cite this

    Haeri, M., & Gilbert, J. L. (2010). Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy. In Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference (pp. 181-185). (Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference).