Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy

M. Haeri; J. L. Gilbert

Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy

M. Haeri, J. L. Gilbert

Department of Biomedical & Chemical Engineering

Research output: Chapter in Book/Entry/Poem › Conference contribution

1 Scopus citations

Abstract

Surface potential of biomedical implants can significantly alter the behavior of the surrounding cells including cell morphology and viability. In this work, the effect of changing the potenial of a CoCr biomedical alloy on the morphology and viability of murine preosteblast cells (MC3T3) was studied. CoCr samples were polarized to cathodic and anodic voltages ranging from -1000 to +500 mv. The morphology and viability were studied using scanning electron microscopy and Live-dead assay techniques, respectively. It was found that voltage significantly influences the cellular response and there exists a voltage viability range, outside of which cells will not be viable. Both anodic (greater than 500 mV) and cathodic (more negative than -100 mV) voltage extremes induced cell death on CoCr surfaces.

Original language	English (US)
Title of host publication	Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference
Pages	181-185
Number of pages	5
State	Published - 2010
Event	5th Materials and Processes for Medical Devices Conference, MPMD - Minneapolis, MN, United States Duration: Aug 10 2009 → Aug 12 2009

Publication series

Name	Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference

Other

Other	5th Materials and Processes for Medical Devices Conference, MPMD
Country/Territory	United States
City	Minneapolis, MN
Period	8/10/09 → 8/12/09

ASJC Scopus subject areas

Biomedical Engineering
Materials Chemistry

Cite this

Haeri, M., & Gilbert, J. L. (2010). Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy. In Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference (pp. 181-185). (Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference).

Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy. / Haeri, M.; Gilbert, J. L.
Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference. 2010. p. 181-185 (Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference).

Research output: Chapter in Book/Entry/Poem › Conference contribution

Haeri, M & Gilbert, JL 2010, Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy. in Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference. Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference, pp. 181-185, 5th Materials and Processes for Medical Devices Conference, MPMD, Minneapolis, MN, United States, 8/10/09.

Haeri, M. ; Gilbert, J. L. / Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy. Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference. 2010. pp. 181-185 (Medical Device Materials V - Proceedings of the Materials and Processes for Medical Devices Conference).

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abstract = "Surface potential of biomedical implants can significantly alter the behavior of the surrounding cells including cell morphology and viability. In this work, the effect of changing the potenial of a CoCr biomedical alloy on the morphology and viability of murine preosteblast cells (MC3T3) was studied. CoCr samples were polarized to cathodic and anodic voltages ranging from -1000 to +500 mv. The morphology and viability were studied using scanning electron microscopy and Live-dead assay techniques, respectively. It was found that voltage significantly influences the cellular response and there exists a voltage viability range, outside of which cells will not be viable. Both anodic (greater than 500 mV) and cathodic (more negative than -100 mV) voltage extremes induced cell death on CoCr surfaces.",

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AB - Surface potential of biomedical implants can significantly alter the behavior of the surrounding cells including cell morphology and viability. In this work, the effect of changing the potenial of a CoCr biomedical alloy on the morphology and viability of murine preosteblast cells (MC3T3) was studied. CoCr samples were polarized to cathodic and anodic voltages ranging from -1000 to +500 mv. The morphology and viability were studied using scanning electron microscopy and Live-dead assay techniques, respectively. It was found that voltage significantly influences the cellular response and there exists a voltage viability range, outside of which cells will not be viable. Both anodic (greater than 500 mV) and cathodic (more negative than -100 mV) voltage extremes induced cell death on CoCr surfaces.

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Cellular response to anodic and cathodic surface voltage, and metal ion release in polarized cocr biomedical alloy

Abstract

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