Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation

Martin A. Dolan, Prem N. Basa, Oleksii Zozulia, Zsófia Lengyel, René Lebl, Eric M. Kohn, Sagar Bhattacharya, Ivan Korendovych

Research output: Contribution to journalArticle

Abstract

Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).

Original languageEnglish (US)
Pages (from-to)9292-9297
Number of pages6
JournalACS nano
Volume13
Issue number8
DOIs
StatePublished - Aug 27 2019

Fingerprint

Enantioselectivity
Ketones
ketones
Self assembly
Peptides
Hydrogenation
hydrogenation
peptides
Metal ions
amino acids
self assembly
Amino acids
emerging
metal ions
Amino Acids

Keywords

  • ATH
  • catalysis
  • enantioselective
  • micelle
  • peptide
  • self-assembly
  • vesicle

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation. / Dolan, Martin A.; Basa, Prem N.; Zozulia, Oleksii; Lengyel, Zsófia; Lebl, René; Kohn, Eric M.; Bhattacharya, Sagar; Korendovych, Ivan.

In: ACS nano, Vol. 13, No. 8, 27.08.2019, p. 9292-9297.

Research output: Contribution to journalArticle

Dolan, MA, Basa, PN, Zozulia, O, Lengyel, Z, Lebl, R, Kohn, EM, Bhattacharya, S & Korendovych, I 2019, 'Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation', ACS nano, vol. 13, no. 8, pp. 9292-9297. https://doi.org/10.1021/acsnano.9b03880
Dolan, Martin A. ; Basa, Prem N. ; Zozulia, Oleksii ; Lengyel, Zsófia ; Lebl, René ; Kohn, Eric M. ; Bhattacharya, Sagar ; Korendovych, Ivan. / Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation. In: ACS nano. 2019 ; Vol. 13, No. 8. pp. 9292-9297.
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