Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation

Martin A. Dolan, Prem N. Basa, Oleksii Zozulia, Zsófia Lengyel, René Lebl, Eric M. Kohn, Sagar Bhattacharya, Ivan V. Korendovych

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Self-assembly enables formation of incredibly diverse supramolecular structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramolecular, vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).

Original languageEnglish (US)
Pages (from-to)9292-9297
Number of pages6
JournalACS nano
Volume13
Issue number8
DOIs
StatePublished - Aug 27 2019

Keywords

  • ATH
  • catalysis
  • enantioselective
  • micelle
  • peptide
  • self-assembly
  • vesicle

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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