Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults: A pilot investigation

Kevin S Heffernan, Nicole L. Spartano, Jacqueline A. Augustine, Wesley K. Lefferts, William E. Hughes, Gary F. Mitchell, Randall Steven Jorgensen, Brooks B Gump

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Arterial stiffness is a prominent determinant of pulsatility in the systemic circulation and may thus indirectly impact NVC. In this pilot investigation, we explored changes in carotid artery stiffness and cerebrovascular hemodynamic pulsatiltiy during cognitive engagement in healthy adults. METHODS Twenty-seven adults (age 39 ± 3 years, BMI 24 ± 1 kg/m2) underwent Doppler ultrasonography of the common carotid artery (CCA) combined with applanation tonometry to derive (i) CCA elastic modulus (Ep) and β-stiffness index; (ii) CCA flow pulsatility index (PI); (iii) CCA pulse pressure, (iv) CCA augmentation index (AIx). Cerebral PI was assessed using transcranial Doppler at the middle cerebral artery (MCA). All measures were made at rest and during an incongruent Stroop task. RESULTS CCA PI was reduced (1.75 ± 0.06 to 1.57 ± 0.06, P < 0.05) while MCA PI was unchanged (0.75 ± 0.02 to 0.75 ± 0.02, P > 0.05) during Stroop. Brachial pulse pressure increased during Stroop (43 ± 1 to 46 ± 1 mm Hg, P < 0.05) while CCA pulse pressure was unchanged (36 ± 1 to 35 ± 1 mm Hg, P > 0.05). Similarly, CCA Ep (54.5 ± 5.5 to 53.8 ± 4.9 kPa, P > 0.05) and β-stiffness index (4.4 ± 0.4 to 4.2 ± 0.3 aU, P > 0.05) were unchanged. CCA AIx increased (1 ± 4 to 13 ± 4%, P < 0.05). CONC LUSION Carotid pressure pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid artery stiffness does not change suggesting that factors other than the dynamic elastic properties of the CCA buffer cerebrovascular hemodynamic pulsatility during cognitive engagement.

Original languageEnglish (US)
Pages (from-to)615-622
Number of pages8
JournalAmerican Journal of Hypertension
Volume28
Issue number5
DOIs
StatePublished - 2015

Fingerprint

Common Carotid Artery
Carotid Arteries
Hemodynamics
Blood Pressure
Doppler Ultrasonography
Vascular Stiffness
Elastic Modulus
Manometry
Middle Cerebral Artery
Blood Vessels
Buffers
Arm
Pressure

Keywords

  • Arterial stiffness
  • Augmentation index
  • Blood pressure
  • Carotid artery
  • Hemodynamics
  • Hypertension
  • Pulsatility

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults : A pilot investigation. / Heffernan, Kevin S; Spartano, Nicole L.; Augustine, Jacqueline A.; Lefferts, Wesley K.; Hughes, William E.; Mitchell, Gary F.; Jorgensen, Randall Steven; Gump, Brooks B.

In: American Journal of Hypertension, Vol. 28, No. 5, 2015, p. 615-622.

Research output: Contribution to journalArticle

Heffernan, Kevin S ; Spartano, Nicole L. ; Augustine, Jacqueline A. ; Lefferts, Wesley K. ; Hughes, William E. ; Mitchell, Gary F. ; Jorgensen, Randall Steven ; Gump, Brooks B. / Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults : A pilot investigation. In: American Journal of Hypertension. 2015 ; Vol. 28, No. 5. pp. 615-622.
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abstract = "Background The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Arterial stiffness is a prominent determinant of pulsatility in the systemic circulation and may thus indirectly impact NVC. In this pilot investigation, we explored changes in carotid artery stiffness and cerebrovascular hemodynamic pulsatiltiy during cognitive engagement in healthy adults. METHODS Twenty-seven adults (age 39 ± 3 years, BMI 24 ± 1 kg/m2) underwent Doppler ultrasonography of the common carotid artery (CCA) combined with applanation tonometry to derive (i) CCA elastic modulus (Ep) and β-stiffness index; (ii) CCA flow pulsatility index (PI); (iii) CCA pulse pressure, (iv) CCA augmentation index (AIx). Cerebral PI was assessed using transcranial Doppler at the middle cerebral artery (MCA). All measures were made at rest and during an incongruent Stroop task. RESULTS CCA PI was reduced (1.75 ± 0.06 to 1.57 ± 0.06, P < 0.05) while MCA PI was unchanged (0.75 ± 0.02 to 0.75 ± 0.02, P > 0.05) during Stroop. Brachial pulse pressure increased during Stroop (43 ± 1 to 46 ± 1 mm Hg, P < 0.05) while CCA pulse pressure was unchanged (36 ± 1 to 35 ± 1 mm Hg, P > 0.05). Similarly, CCA Ep (54.5 ± 5.5 to 53.8 ± 4.9 kPa, P > 0.05) and β-stiffness index (4.4 ± 0.4 to 4.2 ± 0.3 aU, P > 0.05) were unchanged. CCA AIx increased (1 ± 4 to 13 ± 4{\%}, P < 0.05). CONC LUSION Carotid pressure pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid artery stiffness does not change suggesting that factors other than the dynamic elastic properties of the CCA buffer cerebrovascular hemodynamic pulsatility during cognitive engagement.",
keywords = "Arterial stiffness, Augmentation index, Blood pressure, Carotid artery, Hemodynamics, Hypertension, Pulsatility",
author = "Heffernan, {Kevin S} and Spartano, {Nicole L.} and Augustine, {Jacqueline A.} and Lefferts, {Wesley K.} and Hughes, {William E.} and Mitchell, {Gary F.} and Jorgensen, {Randall Steven} and Gump, {Brooks B}",
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T1 - Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults

T2 - A pilot investigation

AU - Heffernan, Kevin S

AU - Spartano, Nicole L.

AU - Augustine, Jacqueline A.

AU - Lefferts, Wesley K.

AU - Hughes, William E.

AU - Mitchell, Gary F.

AU - Jorgensen, Randall Steven

AU - Gump, Brooks B

PY - 2015

Y1 - 2015

N2 - Background The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Arterial stiffness is a prominent determinant of pulsatility in the systemic circulation and may thus indirectly impact NVC. In this pilot investigation, we explored changes in carotid artery stiffness and cerebrovascular hemodynamic pulsatiltiy during cognitive engagement in healthy adults. METHODS Twenty-seven adults (age 39 ± 3 years, BMI 24 ± 1 kg/m2) underwent Doppler ultrasonography of the common carotid artery (CCA) combined with applanation tonometry to derive (i) CCA elastic modulus (Ep) and β-stiffness index; (ii) CCA flow pulsatility index (PI); (iii) CCA pulse pressure, (iv) CCA augmentation index (AIx). Cerebral PI was assessed using transcranial Doppler at the middle cerebral artery (MCA). All measures were made at rest and during an incongruent Stroop task. RESULTS CCA PI was reduced (1.75 ± 0.06 to 1.57 ± 0.06, P < 0.05) while MCA PI was unchanged (0.75 ± 0.02 to 0.75 ± 0.02, P > 0.05) during Stroop. Brachial pulse pressure increased during Stroop (43 ± 1 to 46 ± 1 mm Hg, P < 0.05) while CCA pulse pressure was unchanged (36 ± 1 to 35 ± 1 mm Hg, P > 0.05). Similarly, CCA Ep (54.5 ± 5.5 to 53.8 ± 4.9 kPa, P > 0.05) and β-stiffness index (4.4 ± 0.4 to 4.2 ± 0.3 aU, P > 0.05) were unchanged. CCA AIx increased (1 ± 4 to 13 ± 4%, P < 0.05). CONC LUSION Carotid pressure pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid artery stiffness does not change suggesting that factors other than the dynamic elastic properties of the CCA buffer cerebrovascular hemodynamic pulsatility during cognitive engagement.

AB - Background The matching of vascular supply to neuronal metabolic demand during cognitive engagement is known as neurovascular coupling (NVC). Arterial stiffness is a prominent determinant of pulsatility in the systemic circulation and may thus indirectly impact NVC. In this pilot investigation, we explored changes in carotid artery stiffness and cerebrovascular hemodynamic pulsatiltiy during cognitive engagement in healthy adults. METHODS Twenty-seven adults (age 39 ± 3 years, BMI 24 ± 1 kg/m2) underwent Doppler ultrasonography of the common carotid artery (CCA) combined with applanation tonometry to derive (i) CCA elastic modulus (Ep) and β-stiffness index; (ii) CCA flow pulsatility index (PI); (iii) CCA pulse pressure, (iv) CCA augmentation index (AIx). Cerebral PI was assessed using transcranial Doppler at the middle cerebral artery (MCA). All measures were made at rest and during an incongruent Stroop task. RESULTS CCA PI was reduced (1.75 ± 0.06 to 1.57 ± 0.06, P < 0.05) while MCA PI was unchanged (0.75 ± 0.02 to 0.75 ± 0.02, P > 0.05) during Stroop. Brachial pulse pressure increased during Stroop (43 ± 1 to 46 ± 1 mm Hg, P < 0.05) while CCA pulse pressure was unchanged (36 ± 1 to 35 ± 1 mm Hg, P > 0.05). Similarly, CCA Ep (54.5 ± 5.5 to 53.8 ± 4.9 kPa, P > 0.05) and β-stiffness index (4.4 ± 0.4 to 4.2 ± 0.3 aU, P > 0.05) were unchanged. CCA AIx increased (1 ± 4 to 13 ± 4%, P < 0.05). CONC LUSION Carotid pressure pulsatility is unaltered while carotid flow pulsatility is reduced during cognitive engagement. Carotid artery stiffness does not change suggesting that factors other than the dynamic elastic properties of the CCA buffer cerebrovascular hemodynamic pulsatility during cognitive engagement.

KW - Arterial stiffness

KW - Augmentation index

KW - Blood pressure

KW - Carotid artery

KW - Hemodynamics

KW - Hypertension

KW - Pulsatility

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