TY - JOUR
T1 - Cargo transport
T2 - molecular motors navigate a complex cytoskeleton
AU - Ross, Jennifer L.
AU - Ali, M. Yusuf
AU - Warshaw, David M.
N1 - Funding Information:
JLR would like to thank the Goldman and Holzbaur laboratories and DMW and MYA the Trybus and Warshaw laboratories for numerous discussions that helped formulate our thoughts around issues presented in this review. DMW and MYA were supported by funds from the National Institutes of Health (HL059408, HL085489).
PY - 2008/2
Y1 - 2008/2
N2 - Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again.
AB - Intracellular cargo transport requires microtubule-based motors, kinesin and cytoplasmic dynein, and the actin-based myosin motors to maneuver through the challenges presented by the filamentous meshwork that comprises the cytoskeleton. Recent in vitro single molecule biophysical studies have begun to explore this process by characterizing what occurs as these tiny molecular motors happen upon an intersection between two cytoskeletal filaments. These studies, in combination with in vivo work, define the mechanism by which molecular motors exchange cargo while traveling between filamentous tracks and deliver it to its destination when going from the cell center to the periphery and back again.
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U2 - 10.1016/j.ceb.2007.11.006
DO - 10.1016/j.ceb.2007.11.006
M3 - Review article
C2 - 18226515
AN - SCOPUS:39149138988
SN - 0955-0674
VL - 20
SP - 41
EP - 47
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -