Calmodulin antagonists decrease the binding of epidermal growth factor to transformed, but not to normal, human fibroblasts

P. V. Bodine, J. T. Tupper

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Four psychoactive agents which inhibit calmodulin activity were used to study their effect on the binding of epidermal growth factor (EGF) to normal and simian-virus-40-transformed human fibroblasts (WI38). These calmodulin antagonists decreased the binding of 125I-labelled EGF to the transformed, but not to the normal, cell in a dose-dependent manner. The mechanism of this effect appears to be due to a decrease in the apparent affinity of the plasma-membrane EGF receptor for the EGF molecule.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalBiochemical Journal
Volume218
Issue number2
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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