Calmodulin antagonists decrease the binding of epidermal growth factor to transformed, but not to normal, human fibroblasts

P. V. Bodine, J. T. Tupper

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Four psychoactive agents which inhibit calmodulin activity were used to study their effect on the binding of epidermal growth factor (EGF) to normal and simian-virus-40-transformed human fibroblasts (WI38). These calmodulin antagonists decreased the binding of 125I-labelled EGF to the transformed, but not to the normal, cell in a dose-dependent manner. The mechanism of this effect appears to be due to a decrease in the apparent affinity of the plasma-membrane EGF receptor for the EGF molecule.

Original languageEnglish (US)
Pages (from-to)629-632
Number of pages4
JournalBiochemical Journal
Volume218
Issue number2
DOIs
StatePublished - 1984

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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