TY - JOUR
T1 - Branching, capping, and severing in dynamic actin structures
AU - Gopinathan, Ajay
AU - Lee, Kun Chun
AU - Schwarz, J. M.
AU - Liu, Andrea J.
PY - 2007/8/2
Y1 - 2007/8/2
N2 - Branched actin networks at the leading edge of a crawling cell evolve via protein-regulated processes such as polymerization, depolymerization, capping, branching, and severing. A formulation of these processes is presented and analyzed to study steady-state network morphology. In bulk, we identify several scaling regimes in severing and branching protein concentrations and find that the coupling between severing and branching is optimally exploited for conditions in vivo. Near the leading edge, we find qualitative agreement with the in vivo morphology.
AB - Branched actin networks at the leading edge of a crawling cell evolve via protein-regulated processes such as polymerization, depolymerization, capping, branching, and severing. A formulation of these processes is presented and analyzed to study steady-state network morphology. In bulk, we identify several scaling regimes in severing and branching protein concentrations and find that the coupling between severing and branching is optimally exploited for conditions in vivo. Near the leading edge, we find qualitative agreement with the in vivo morphology.
UR - http://www.scopus.com/inward/record.url?scp=34547692511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547692511&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.99.058103
DO - 10.1103/PhysRevLett.99.058103
M3 - Article
C2 - 17930797
AN - SCOPUS:34547692511
SN - 0031-9007
VL - 99
JO - Physical Review Letters
JF - Physical Review Letters
IS - 5
M1 - 058103
ER -