Biosynthetic incorporation of the azulene moiety in proteins with high efficiency

Jinfeng Shao; Ivan V. Korendovych; Jaap Broos

doi:10.1007/s00726-014-1870-4

Biosynthetic incorporation of the azulene moiety in proteins with high efficiency

Jinfeng Shao, Ivan V. Korendovych, Jaap Broos

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Biosynthetic incorporation of β-(1-azulenyl)-l-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.

Original language	English (US)
Pages (from-to)	213-216
Number of pages	4
Journal	Amino Acids
Volume	47
Issue number	1
DOIs	https://doi.org/10.1007/s00726-014-1870-4
State	Published - Jan 1 2015

Keywords

Fluorescence
Lactococcus lactis
Spectroscopic probe
Tryptophan analog
Tryptophanyl-tRNA synthetase

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Clinical Biochemistry

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10.1007/s00726-014-1870-4

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title = "Biosynthetic incorporation of the azulene moiety in proteins with high efficiency",

abstract = "Biosynthetic incorporation of β-(1-azulenyl)-l-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.",

keywords = "Fluorescence, Lactococcus lactis, Spectroscopic probe, Tryptophan analog, Tryptophanyl-tRNA synthetase",

author = "Jinfeng Shao and Korendovych, {Ivan V.} and Jaap Broos",

note = "Publisher Copyright: {\textcopyright} 2014 Springer-Verlag Wien.",

year = "2015",

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doi = "10.1007/s00726-014-1870-4",

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T1 - Biosynthetic incorporation of the azulene moiety in proteins with high efficiency

AU - Shao, Jinfeng

AU - Korendovych, Ivan V.

AU - Broos, Jaap

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Biosynthetic incorporation of β-(1-azulenyl)-l-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.

AB - Biosynthetic incorporation of β-(1-azulenyl)-l-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.

KW - Fluorescence

KW - Lactococcus lactis

KW - Spectroscopic probe

KW - Tryptophan analog

KW - Tryptophanyl-tRNA synthetase

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Biosynthetic incorporation of the azulene moiety in proteins with high efficiency

Abstract

Keywords

ASJC Scopus subject areas

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