Biosynthetic incorporation of the azulene moiety in proteins with high efficiency

Jinfeng Shao, Ivan V. Korendovych, Jaap Broos

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Biosynthetic incorporation of β-(1-azulenyl)-l-alanine, an isostere of tryptophan, is reported using a tryptophan auxotroph expression host. The azulene moiety introduced this way in proteins features many attractive spectroscopic properties, particularly suitable for in vivo studies.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalAmino Acids
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • Fluorescence
  • Lactococcus lactis
  • Spectroscopic probe
  • Tryptophan analog
  • Tryptophanyl-tRNA synthetase

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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