TY - JOUR
T1 - Biostable shape memory polymer foams for smart biomaterial applications
AU - Vakil, Anand Utpal
AU - Petryk, Natalie Marie
AU - Shepherd, Ellen
AU - Monroe, Mary Beth B.
N1 - Funding Information:
Funding: This material is based on research sponsored by U.S. Air Force under agreement number FA8650-18-2-6978. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposed, notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors. They should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of U.S. Air Force or the U.S. Government.
Funding Information:
This material is based on research sponsored by U.S. Air Force under agreement number FA8650-18-2-6978. The U.S. Government is authorized to reproduce and distribute reprints for Governmental purposed, notwithstanding any copyright notation thereon. The views and con-clusions contained herein are those of the authors. They should not be interpreted as necessarily representing the official policies or endorsements, either expressed or implied, of U.S. Air Force or the U.S. Government.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Polyurethane foams provide a wide range of applications as a biomaterial system due to the ability to tune their physical, chemical, and biological properties to meet the requirements of the intended applications. Another key parameter that determines the usability of this biomaterial is its degradability under body conditions. Several current approaches focus on slowing the degradation rate for applications that require the implant to be present for a longer time frame (over 100 days). Here, biostable shape memory polymer (SMP) foams were synthesized with added ether-containing monomers to tune the degradation rates. The physical, thermal and shape memory properties of these foams were characterized along with their cytocompatibility and blood interactions. Degradation profiles were assessed in vitro in oxidative (3% H2O2; real-time) and hydrolytic media (0.1 M NaOH; accelerated) at 37◦C. The resulting foams had tunable degradation rates, with up 15% mass remaining after 108 days, and controlled erosion profiles. These easy-to-use, shape-filling SMP foams have the potential for various biomaterial applications where longer-term stability without the need for implant removal is desired.
AB - Polyurethane foams provide a wide range of applications as a biomaterial system due to the ability to tune their physical, chemical, and biological properties to meet the requirements of the intended applications. Another key parameter that determines the usability of this biomaterial is its degradability under body conditions. Several current approaches focus on slowing the degradation rate for applications that require the implant to be present for a longer time frame (over 100 days). Here, biostable shape memory polymer (SMP) foams were synthesized with added ether-containing monomers to tune the degradation rates. The physical, thermal and shape memory properties of these foams were characterized along with their cytocompatibility and blood interactions. Degradation profiles were assessed in vitro in oxidative (3% H2O2; real-time) and hydrolytic media (0.1 M NaOH; accelerated) at 37◦C. The resulting foams had tunable degradation rates, with up 15% mass remaining after 108 days, and controlled erosion profiles. These easy-to-use, shape-filling SMP foams have the potential for various biomaterial applications where longer-term stability without the need for implant removal is desired.
KW - Biostable
KW - Degradation
KW - Foams
KW - Oxidation
KW - Polyurethanes
KW - Shape memory polymers
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UR - http://www.scopus.com/inward/citedby.url?scp=85119997422&partnerID=8YFLogxK
U2 - 10.3390/polym13234084
DO - 10.3390/polym13234084
M3 - Article
AN - SCOPUS:85119997422
SN - 2073-4360
VL - 13
JO - Polymers
JF - Polymers
IS - 23
M1 - 4084
ER -